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Showing results (221-230 of 240) with videos related to

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Journal of Medicinal Chemistry|September 11, 2018
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N<sup>2</sup>-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N<sup>8</sup>-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722)Hannah L Woodward, Paolo Innocenti, Kwai-Ming J Cheung, et al.
Journal of Medicinal Chemistry|November 22, 2013
Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1)Sébastien Naud, Isaac M Westwood, Amir Faisal, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|July 12, 2012
AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activityTimothy A Yap, Mike I Walton, Kyla M Grimshaw, et al.
Journal of Medicinal Chemistry|January 23, 2016
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19Aurélie Mallinger, Kai Schiemann, Christian Rink, et al.
Journal of Medicinal Chemistry|April 8, 2016
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization ApproachPaolo Innocenti, Hannah L Woodward, Savade Solanki, et al.
Journal of Medicinal Chemistry|December 23, 2016
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic ScreenMatthew D Cheeseman, Nicola E A Chessum, Carl S Rye, et al.
Gut|August 10, 2017
Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II studyKhurum Khan, Mihaela Rata, David Cunningham, et al.
Nature Chemical Biology|October 27, 2015
A selective chemical probe for exploring the role of CDK8 and CDK19 in human diseaseTrevor Dale, Paul A Clarke, Christina Esdar, et al.
Nature Immunology|November 19, 2021
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote T<sub>H</sub>2 and inhibit T<sub>H</sub>17 cell polarizationJohannes U Mayer, Kerry L Hilligan, Jodie S Chandler, et al.
Elife|December 10, 2016
Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinasesPaul A Clarke, Maria-Jesus Ortiz-Ruiz, Robert TePoele, et al.
Pageof 24

Showing results (221-230 of 240) with videos related to

Sort By:
Pageof 24
Journal of Medicinal Chemistry|September 11, 2018
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N<sup>2</sup>-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N<sup>8</sup>-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722)Hannah L Woodward, Paolo Innocenti, Kwai-Ming J Cheung, et al.
Journal of Medicinal Chemistry|November 22, 2013
Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1)Sébastien Naud, Isaac M Westwood, Amir Faisal, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|July 12, 2012
AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activityTimothy A Yap, Mike I Walton, Kyla M Grimshaw, et al.
Journal of Medicinal Chemistry|January 23, 2016
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19Aurélie Mallinger, Kai Schiemann, Christian Rink, et al.
Journal of Medicinal Chemistry|April 8, 2016
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization ApproachPaolo Innocenti, Hannah L Woodward, Savade Solanki, et al.
Journal of Medicinal Chemistry|December 23, 2016
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic ScreenMatthew D Cheeseman, Nicola E A Chessum, Carl S Rye, et al.
Gut|August 10, 2017
Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II studyKhurum Khan, Mihaela Rata, David Cunningham, et al.
Nature Chemical Biology|October 27, 2015
A selective chemical probe for exploring the role of CDK8 and CDK19 in human diseaseTrevor Dale, Paul A Clarke, Christina Esdar, et al.
Nature Immunology|November 19, 2021
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote T<sub>H</sub>2 and inhibit T<sub>H</sub>17 cell polarizationJohannes U Mayer, Kerry L Hilligan, Jodie S Chandler, et al.
Elife|December 10, 2016
Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinasesPaul A Clarke, Maria-Jesus Ortiz-Ruiz, Robert TePoele, et al.
Pageof 24