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The Biochemical Journal|August 15, 1995
Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluidsA J Fosang, K Last, P Gardiner, et al.
The Journal of Clinical Investigation|November 15, 1996
Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independentA J Fosang, K Last, R A Maciewicz
Matrix Biology : Journal of the International Society for Matrix Biology|December 2, 2008
Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecanA J Fosang, K Last, C J Poon, et al.
FEBS Letters|September 1, 2005
Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycanS Knox, A J Fosang, K Last, et al.
FEBS Letters|August 4, 1998
Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domainA J Fosang, K Last, Y Fujii, et al.
FEBS Letters|February 12, 1996
Degradation of cartilage aggrecan by collagenase-3 (MMP-13)A J Fosang, K Last, V Knäuper, et al.
The Journal of Biological Chemistry|October 18, 2000
Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activityF A Mercuri, R A Maciewicz, J Tart, et al.
The Journal of Biological Chemistry|September 25, 1992
The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin BA J Fosang, P J Neame, K Last, et al.
The Journal of Biological Chemistry|November 5, 1999
Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanaseF A Mercuri, K J Doege, E C Arner, et al.
The Journal of Biological Chemistry|July 7, 2000
Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explantsA J Fosang, K Last, H Stanton, et al.
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