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British Journal of Cancer|May 1, 1995
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell linesA L Jackman, L R Kelland, R Kimbell, et al.
European Journal of Cancer (Oxford, England : 1990)|July 1, 1995
ZD1694 (Tomudex): a new thymidylate synthase inhibitor with activity in colorectal cancerA L Jackman, D C Farrugia, W Gibson, et al.
Cancer Research|October 15, 1991
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical studyA L Jackman, G A Taylor, W Gibson, et al.
Cancer Chemotherapy and Pharmacology|January 1, 1980
The clinical pharmacology of the adenosine deaminase inhibitor 2'-deoxycoformycinJ F Smyth, R M Paine, A L Jackman, et al.
Journal of Medicinal Chemistry|April 1, 1986
Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modificationsT R Jones, M J Smithers, M A Taylor, et al.
British Journal of Cancer|February 14, 1998
Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical modelsG W Aherne, E Ward, N Lawrence, et al.
Journal of Medicinal Chemistry|July 24, 1992
Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituentsP Warner, A J Barker, A L Jackman, et al.
Anti-Cancer Drug Design|October 1, 1995
Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamationA L Jackman, R Kimbell, M Brown, et al.
Biochemical Pharmacology|October 24, 1991
The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)A L Jackman, D R Newell, W Gibson, et al.
Cancer Research|July 15, 1993
bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathwaysT C Fisher, A E Milner, C D Gregory, et al.
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