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Journal of Medicinal Chemistry
|
September 6, 2008
Multiple and single binding modes of fragment-like kinase inhibitors revealed by molecular modeling, residue type-selective protonation, and nuclear overhauser effects
Keith L Constantine, Luciano Mueller, William J Metzler, et al.
Acta Crystallographica. Section F, Structural Biology Communications
|
October 14, 2024
Improving the diffraction quality of heat-shock protein 47 crystals
Kevin Kish, Stephen Cobell, Nicolas Szapiel, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
March 14, 2018
Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form
Micah T Nelp, Patrick A Kates, John T Hunt, et al.
Cancer Research
|
June 3, 2006
The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants
John S Tokarski, John A Newitt, Chieh Ying J Chang, et al.
Nature Communications
|
July 2, 2025
Orthosteric STING inhibition elucidates molecular correction of SAVI STING
Tao Xie, Max Ruzanov, David Critton, et al.
Journal of Medicinal Chemistry
|
March 13, 2015
Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening
Daniel L Cheney, Jeffrey M Bozarth, William J Metzler, et al.
Bioorganic & Medicinal Chemistry Letters
|
August 25, 2010
Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors
Shuqun Lin, Stephen T Wrobleski, John Hynes, et al.
Bioorganic & Medicinal Chemistry Letters
|
February 7, 2006
Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series
Christine M Tarby, Robert F Kaltenbach, Tram Huynh, et al.
Bioorganic & Medicinal Chemistry Letters
|
April 8, 2015
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core
Prasanna Sivaprakasam, Xiaojun Han, Rita L Civiello, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 2, 2010
5-amino-pyrazoles as potent and selective p38α inhibitors
Jagabandhu Das, Robert V Moquin, Alaric J Dyckman, et al.
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Search research articles
Search
Showing results (21-30 of 41) with videos related to
Sort By:
Page
of 5
Journal of Medicinal Chemistry
|
September 6, 2008
Multiple and single binding modes of fragment-like kinase inhibitors revealed by molecular modeling, residue type-selective protonation, and nuclear overhauser effects
Keith L Constantine, Luciano Mueller, William J Metzler, et al.
Acta Crystallographica. Section F, Structural Biology Communications
|
October 14, 2024
Improving the diffraction quality of heat-shock protein 47 crystals
Kevin Kish, Stephen Cobell, Nicolas Szapiel, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
March 14, 2018
Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form
Micah T Nelp, Patrick A Kates, John T Hunt, et al.
Cancer Research
|
June 3, 2006
The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants
John S Tokarski, John A Newitt, Chieh Ying J Chang, et al.
Nature Communications
|
July 2, 2025
Orthosteric STING inhibition elucidates molecular correction of SAVI STING
Tao Xie, Max Ruzanov, David Critton, et al.
Journal of Medicinal Chemistry
|
March 13, 2015
Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening
Daniel L Cheney, Jeffrey M Bozarth, William J Metzler, et al.
Bioorganic & Medicinal Chemistry Letters
|
August 25, 2010
Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors
Shuqun Lin, Stephen T Wrobleski, John Hynes, et al.
Bioorganic & Medicinal Chemistry Letters
|
February 7, 2006
Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series
Christine M Tarby, Robert F Kaltenbach, Tram Huynh, et al.
Bioorganic & Medicinal Chemistry Letters
|
April 8, 2015
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core
Prasanna Sivaprakasam, Xiaojun Han, Rita L Civiello, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 2, 2010
5-amino-pyrazoles as potent and selective p38α inhibitors
Jagabandhu Das, Robert V Moquin, Alaric J Dyckman, et al.
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