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Biopolymers|March 4, 2000
X-ray crystallographic analysis of the hydration of A- and B-form DNA at atomic resolutionM Egli, V Tereshko, M Teplova, et al.
Nucleic Acids Research|August 15, 1997
In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cellsM K Bijsterbosch, M Manoharan, E T Rump, et al.
The Journal of Organic Chemistry|March 5, 2016
Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified OligonucleotidesAlexander V Kel'in, Ivan Zlatev, Joel Harp, et al.
Proceedings of the National Academy of Sciences of the United States of America|October 18, 2007
Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficitsM DiFiglia, M Sena-Esteves, K Chase, et al.
The Journal of Pharmacology and Experimental Therapeutics|May 1, 1996
Pharmacokinetic properties of several novel oligonucleotide analogs in miceS T Crooke, M J Graham, J E Zuckerman, et al.
Nucleic Acids Research|July 16, 2021
Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivoHartmut Jahns, Nate Taneja, Jennifer L S Willoughby, et al.
ACS Chemical Biology|March 3, 2015
siRNA conjugates carrying sequentially assembled trivalent N-acetylgalactosamine linked through nucleosides elicit robust gene silencing in vivo in hepatocytesShigeo Matsuda, Kristofer Keiser, Jayaprakash K Nair, et al.
Journal of the American Chemical Society|September 23, 2017
4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene SilencingElise Malek-Adamian, Dale C Guenther, Shigeo Matsuda, et al.
Journal of Medicinal Chemistry|February 9, 2023
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC PathwaysPachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, et al.
Journal of the American Chemical Society|August 28, 2023
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAsShigeo Matsuda, Saikat Bala, Jen-Yu Liao, et al.
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