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Journal of Medicinal Chemistry|December 1, 1983
Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activityA Rosowsky, R Forsch, J Uren, et al.Cancer Chemotherapy and Pharmacology|September 23, 1998
Pharmacokinetics, antifolate activity and tissue distribution of PT523 in SCC VII tumor-bearing miceJ E Wright, M Pardo, A Tretyakov, et al.Biochemistry|April 15, 1997
NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate reductaseJ M Johnson, E M Meiering, J E Wright, et al.Journal of Medicinal Chemistry|July 1, 1988
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activityA Rosowsky, H Bader, C A Cucchi, et al.Cancer Research|September 1, 1979
A Phase 1 study of high doses of aminopterin with leucovorin rescue in patients with advanced metastatic tumorsL M Glode, S W Pitman, W D Ensminger, et al.Cancer Research|September 1, 1986
Alkylating agents: in vitro studies of cross-resistance patterns in human cell linesB A Teicher, C A Cucchi, J B Lee, et al.Journal of Medicinal Chemistry|September 1, 1986
Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexateA Rosowsky, H Bader, M Radike-Smith, et al.NCI Monographs : a Publication of the National Cancer Institute|January 1, 1987
Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetaseA Rosowsky, R G Moran, J H Freisheim, et al.Antimicrobial Agents and Chemotherapy|March 18, 2000
Identification of Cryptosporidium parvum dihydrofolate reductase inhibitors by complementation in Saccharomyces cerevisiaeV H Brophy, J Vasquez, R G Nelson, et al.Journal of Medicinal Chemistry|March 3, 1995
2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondiiA Rosowsky, C E Mota, S F Queener, et al.Pageof 43