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The Journal of Clinical Investigation|July 15, 2020
Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytesMarc Pfefferlé, Giada Ingoglia, Christian A Schaer, et al.Cell Death and Differentiation|October 11, 2014
Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stressF Vallelian, J W Deuel, L Opitz, et al.Plos One|May 11, 2010
Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulationAdam D Cohen, David A Schaer, Cailian Liu, et al.BMC Biotechnology|March 17, 2018
Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeuticsChristian A Schaer, Catherine Owczarek, Jeremy W Deuel, et al.Plos One|July 18, 2022
Treatment with a VEGFR-2 antibody results in intra-tumor immune modulation and enhances anti-tumor efficacy of PD-L1 blockade in syngeneic murine tumor modelsYanxia Li, Nelusha Amaladas, Marguerita O'Mahony, et al.Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism|June 9, 2021
Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injuryKevin Akeret, Raphael M Buzzi, Christian A Schaer, et al.American Journal of Respiratory and Critical Care Medicine|December 24, 2015
Haptoglobin Preserves Vascular Nitric Oxide Signaling during HemolysisChristian A Schaer, Jeremy W Deuel, Daniela Schildknecht, et al.Journal for Immunotherapy of Cancer|June 6, 2018
Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockadeRikke B Holmgaard, David A Schaer, Yanxia Li, et al.The Journal of Clinical Investigation|August 28, 2019
Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasmMichael Hugelshofer, Raphael M Buzzi, Christian A Schaer, et al.Cell Reports|March 15, 2018
The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint BlockadeDavid A Schaer, Richard P Beckmann, Jack A Dempsey, et al.Pageof 8