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ACS Medicinal Chemistry Letters
|
December 1, 2015
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment
Mark Ammirati, Scott W Bagley, Samit K Bhattacharya, et al.
Structure (London, England : 1993)
|
July 29, 2014
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms
Matthew F Calabrese, Francis Rajamohan, Melissa S Harris, et al.
Journal of Medicinal Chemistry
|
September 10, 2020
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose
Kentaro Futatsugi, Aaron C Smith, Meihua Tu, et al.
Journal of Medicinal Chemistry
|
August 19, 2020
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Kim Huard, Aaron C Smith, Gregg Cappon, et al.
Journal of Medicinal Chemistry
|
August 5, 2016
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy
Kimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, et al.
Journal of Medicinal Chemistry
|
February 21, 2023
Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss
Michelle R Garnsey, Aaron C Smith, Jana Polivkova, et al.
Journal of Medicinal Chemistry
|
August 31, 2017
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)
Kim Huard, Kay Ahn, Paul Amor, et al.
Journal of Medicinal Chemistry
|
February 22, 2018
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK)
David J Edmonds, Daniel W Kung, Amit S Kalgutkar, et al.
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Search research articles
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Showing results (21-30 of 28) with videos related to
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You have reached the last page of results.
This site can display upto 28 results.
ACS Medicinal Chemistry Letters
|
December 1, 2015
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment
Mark Ammirati, Scott W Bagley, Samit K Bhattacharya, et al.
Structure (London, England : 1993)
|
July 29, 2014
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms
Matthew F Calabrese, Francis Rajamohan, Melissa S Harris, et al.
Journal of Medicinal Chemistry
|
September 10, 2020
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose
Kentaro Futatsugi, Aaron C Smith, Meihua Tu, et al.
Journal of Medicinal Chemistry
|
August 19, 2020
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Kim Huard, Aaron C Smith, Gregg Cappon, et al.
Journal of Medicinal Chemistry
|
August 5, 2016
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy
Kimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, et al.
Journal of Medicinal Chemistry
|
February 21, 2023
Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss
Michelle R Garnsey, Aaron C Smith, Jana Polivkova, et al.
Journal of Medicinal Chemistry
|
August 31, 2017
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)
Kim Huard, Kay Ahn, Paul Amor, et al.
Journal of Medicinal Chemistry
|
February 22, 2018
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK)
David J Edmonds, Daniel W Kung, Amit S Kalgutkar, et al.
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of 3