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ACS Chemical Neuroscience|April 22, 2018

Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide ScaffoldAaron M Bender, Hyekyung P Cho, Kellie D Nance, et al.

ACS Pharmacology & Translational Science|August 23, 2021

Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic EfficacyMark S Moehle, Aaron M Bender, Jonathan W Dickerson, et al.

ACS Medicinal Chemistry Letters|December 18, 2024

Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5Elizabeth S Childress, Rory A Capstick, Katherine E Crocker, et al.

ACS Medicinal Chemistry Letters|May 14, 2025

Discovery of Thieno[3,2-b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5Katherine E Crocker, Scott H Henderson, Rory A Capstick, et al.

Bioorganic & Medicinal Chemistry Letters|December 4, 2018

The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidateJoseph D Panarese, Darren W Engers, Yong-Jin Wu, et al.

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ACS Chemical Neuroscience|April 22, 2018

Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide ScaffoldAaron M Bender, Hyekyung P Cho, Kellie D Nance, et al.

ACS Pharmacology & Translational Science|August 23, 2021

Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic EfficacyMark S Moehle, Aaron M Bender, Jonathan W Dickerson, et al.

ACS Medicinal Chemistry Letters|December 18, 2024

Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5Elizabeth S Childress, Rory A Capstick, Katherine E Crocker, et al.

ACS Medicinal Chemistry Letters|May 14, 2025

Discovery of Thieno[3,2-b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5Katherine E Crocker, Scott H Henderson, Rory A Capstick, et al.

Bioorganic & Medicinal Chemistry Letters|December 4, 2018

The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidateJoseph D Panarese, Darren W Engers, Yong-Jin Wu, et al.

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