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International Journal of Radiation Oncology, Biology, Physics|September 18, 2007
Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: comparison of the dinitrobenzamide mustard PR-104A and tirapazamineKevin O Hicks, Hilary Myint, Adam V Patterson, et al.
The Journal of Gene Medicine|May 12, 2012
Single agent- and combination treatment with two targeted suicide gene therapy systems is effective in chemoresistant small cell lung cancer cellsSigne R Michaelsen, Camilla L Christensen, Maxwell Sehested, et al.
The Journal of Biological Chemistry|November 8, 2013
Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependenceJiechuang Su, Yongchuan Gu, Frederik B Pruijn, et al.
The Journal of Gene Medicine|December 8, 2011
Characterisation of enzyme prodrug gene therapy combinations in coated spheroids and vascular networks in vitroMichelle A Hunt, Dan Li, Michael P Hay, et al.
Molecular Cancer Therapeutics|June 11, 2009
Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104AYongchuan Gu, Adam V Patterson, Graham J Atwell, et al.
Cancers|November 9, 2013
The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug TherapyLaura K Green, Mathew A Storey, Elsie M Williams, et al.
Bioorganic & Medicinal Chemistry Letters|March 20, 2019
Prototyping kinase inhibitor-cytotoxin anticancer mutual prodrugs activated by tumour hypoxia: A chemical proof of concept studyGeraud N Sansom, Nicholas S Kirk, Christopher P Guise, et al.
European Journal of Medicinal Chemistry|June 2, 2019
Synthesis and antiproliferative activity of culicinin D analogues containing simplified AHMOD-based residuesLouise A Stubbing, Iman Kavianinia, Maria R Abbattista, et al.
Bioorganic & Medicinal Chemistry Letters|April 2, 2020
Alanine scan-guided synthesis and biological evaluation of analogues of culicinin D, a potent anticancer peptaibolIman Kavianinia, Louise A Stubbing, Maria R Abbattista, et al.
Journal of Medicinal Chemistry|March 1, 2007
Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapyGraham J Atwell, Shangjin Yang, Frederik B Pruijn, et al.
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