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Adel Moussa

Showing results (11-20 of 26) with videos related to

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Expert Opinion on Investigational Drugs|January 24, 2024
Bemnifosbuvir (BEM, AT-527), a novel nucleotide analogue inhibitor of the hepatitis C virus NS5B polymeraseXiao-Jian Zhou, Steven S Good, Keith Pietropaolo, et al.
Plos Biology|August 27, 2024
The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolutionAurélie Chazot, Claire Zimberger, Mikael Feracci, et al.
Antimicrobial Agents and Chemotherapy|August 23, 2021
Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with <i>In Vitro</i> and <i>In Vivo</i> Activity against Dengue and Other FlavivirusesSteven S Good, Ashleigh Shannon, Kai Lin, et al.
Antimicrobial Agents and Chemotherapy|February 9, 2021
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 <i>In Vitro</i> and a Promising Oral Antiviral for Treatment of COVID-19Steven S Good, Jonna Westover, Kie Hoon Jung, et al.
The Journal of Organic Chemistry|January 24, 2015
Synthesis of 2,3-dideoxy-2-fluoro-2,3-endo-methylene- and 2,3-Dideoxy-2-fluoro-3-C-hydroxymethyl-2,3-endo-methylene-pentofuranoses and their use in the preparation of conformationally locked bicyclic nucleosidesRob Clarkson, Zofia Komsta, Benjamin A Mayes, et al.
Organic Letters|September 12, 2014
Stereoselective cyclopropanation in the synthesis of 3'-deoxy-3'-C-hydroxymethyl-2',3'-methylene-uridineZofia Komsta, Benjamin A Mayes, Adel Moussa, et al.
Bioorganic & Medicinal Chemistry Letters|May 13, 2014
Synthesis of 2'-O,4'-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymeraseChristopher Chapron, Rebecca Glen, Massimiliano La Colla, et al.
Proceedings of the National Academy of Sciences of the United States of America|June 9, 2026
Consecutive catalytic steps of viral RNA polymerase and exonuclease suggest a way to overcome intrinsic nucleotide analogue resistanceAshleigh Shannon, Véronique Fattorini, Candice Sartre, et al.
Antimicrobial Agents and Chemotherapy|October 2, 2019
Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosisElina Berliba, Maxim Bogus, Frédéric Vanhoutte, et al.
Nucleic Acids Research|December 14, 2023
An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complexAshleigh Shannon, Aurélie Chazot, Mikael Feracci, et al.
Pageof 3

Showing results (11-20 of 26) with videos related to

Sort By:
Pageof 3
Expert Opinion on Investigational Drugs|January 24, 2024
Bemnifosbuvir (BEM, AT-527), a novel nucleotide analogue inhibitor of the hepatitis C virus NS5B polymeraseXiao-Jian Zhou, Steven S Good, Keith Pietropaolo, et al.
Plos Biology|August 27, 2024
The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolutionAurélie Chazot, Claire Zimberger, Mikael Feracci, et al.
Antimicrobial Agents and Chemotherapy|August 23, 2021
Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with <i>In Vitro</i> and <i>In Vivo</i> Activity against Dengue and Other FlavivirusesSteven S Good, Ashleigh Shannon, Kai Lin, et al.
Antimicrobial Agents and Chemotherapy|February 9, 2021
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 <i>In Vitro</i> and a Promising Oral Antiviral for Treatment of COVID-19Steven S Good, Jonna Westover, Kie Hoon Jung, et al.
The Journal of Organic Chemistry|January 24, 2015
Synthesis of 2,3-dideoxy-2-fluoro-2,3-endo-methylene- and 2,3-Dideoxy-2-fluoro-3-C-hydroxymethyl-2,3-endo-methylene-pentofuranoses and their use in the preparation of conformationally locked bicyclic nucleosidesRob Clarkson, Zofia Komsta, Benjamin A Mayes, et al.
Organic Letters|September 12, 2014
Stereoselective cyclopropanation in the synthesis of 3'-deoxy-3'-C-hydroxymethyl-2',3'-methylene-uridineZofia Komsta, Benjamin A Mayes, Adel Moussa, et al.
Bioorganic & Medicinal Chemistry Letters|May 13, 2014
Synthesis of 2'-O,4'-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymeraseChristopher Chapron, Rebecca Glen, Massimiliano La Colla, et al.
Proceedings of the National Academy of Sciences of the United States of America|June 9, 2026
Consecutive catalytic steps of viral RNA polymerase and exonuclease suggest a way to overcome intrinsic nucleotide analogue resistanceAshleigh Shannon, Véronique Fattorini, Candice Sartre, et al.
Antimicrobial Agents and Chemotherapy|October 2, 2019
Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosisElina Berliba, Maxim Bogus, Frédéric Vanhoutte, et al.
Nucleic Acids Research|December 14, 2023
An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complexAshleigh Shannon, Aurélie Chazot, Mikael Feracci, et al.
Pageof 3