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Adrian M Isaacs

Showing results (81-90 of 96) with videos related to

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Nature Neuroscience|December 19, 2018
TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression ratesFlorent Laferrière, Zuzanna Maniecka, Manuela Pérez-Berlanga, et al.
Nucleic Acids Research|June 2, 2020
FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retentionJack Humphrey, Nicol Birsa, Carmelo Milioto, et al.
Brain : a Journal of Neurology|July 15, 2011
A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathiesTammaryn Lashley, Jonathan D Rohrer, Rina Bandopadhyay, et al.
American Journal of Human Genetics|February 26, 2013
Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK populationJon Beck, Mark Poulter, Davina Hensman, et al.
Acta Neuropathologica Communications|September 17, 2024
Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoidsAstrid T van der Geest, Channa E Jakobs, Tijana Ljubikj, et al.
Neurobiology of Aging|September 3, 2014
Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansionPietro Fratta, James M Polke, Jia Newcombe, et al.
Biorxiv : the Preprint Server for Biology|July 15, 2024
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4Femke M Feringa, Sascha J Koppes-den Hertog, Lian Wang, et al.
Nature Communications|January 8, 2025
Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivoLiam Kempthorne, Deniz Vaizoglu, Alexander J Cammack, et al.
Cell Reports|May 11, 2025
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neuronsBenedikt V Hölbling, Yashica Gupta, Paolo M Marchi, et al.
Nature Communications|July 6, 2017
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficitsGuillaume M Hautbergue, Lydia M Castelli, Laura Ferraiuolo, et al.
Pageof 10

Showing results (81-90 of 96) with videos related to

Sort By:
Pageof 10
Nature Neuroscience|December 19, 2018
TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression ratesFlorent Laferrière, Zuzanna Maniecka, Manuela Pérez-Berlanga, et al.
Nucleic Acids Research|June 2, 2020
FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retentionJack Humphrey, Nicol Birsa, Carmelo Milioto, et al.
Brain : a Journal of Neurology|July 15, 2011
A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathiesTammaryn Lashley, Jonathan D Rohrer, Rina Bandopadhyay, et al.
American Journal of Human Genetics|February 26, 2013
Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK populationJon Beck, Mark Poulter, Davina Hensman, et al.
Acta Neuropathologica Communications|September 17, 2024
Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoidsAstrid T van der Geest, Channa E Jakobs, Tijana Ljubikj, et al.
Neurobiology of Aging|September 3, 2014
Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansionPietro Fratta, James M Polke, Jia Newcombe, et al.
Biorxiv : the Preprint Server for Biology|July 15, 2024
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4Femke M Feringa, Sascha J Koppes-den Hertog, Lian Wang, et al.
Nature Communications|January 8, 2025
Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivoLiam Kempthorne, Deniz Vaizoglu, Alexander J Cammack, et al.
Cell Reports|May 11, 2025
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neuronsBenedikt V Hölbling, Yashica Gupta, Paolo M Marchi, et al.
Nature Communications|July 6, 2017
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficitsGuillaume M Hautbergue, Lydia M Castelli, Laura Ferraiuolo, et al.
Pageof 10