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Journal of Medicinal Chemistry|April 14, 2017
First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent DiseasesMohamed Salah, Ahmed S Abdelsamie, Martin FrotscherMolecular and Cellular Endocrinology|October 19, 2018
Inhibitors of 17β-hydroxysteroid dehydrogenase type 1, 2 and 14: Structures, biological activities and future challengesMohamed Salah, Ahmed S Abdelsamie, Martin FrotscherJournal of Medicinal Chemistry|August 22, 2022
Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of EndometriosisAbdelrahman Mohamed, Mohamed Salah, Mariam Tahoun, et al.European Journal of Medicinal Chemistry|June 16, 2014
Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linkerAhmed S Abdelsamie, Emmanuel Bey, Nina Hanke, et al.European Journal of Medicinal Chemistry|September 1, 2015
Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzymeAhmed S Abdelsamie, Emmanuel Bey, Emanuele M Gargano, et al.Journal of Medicinal Chemistry|June 27, 2023
Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse ModelMohamed Salah, Mariam Tahoun, Jeannette Rudzitis-Auth, et al.European Journal of Medicinal Chemistry|June 9, 2019
Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17β-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluationAhmed S Abdelsamie, Mohamed Salah, Lorenz Siebenbürger, et al.Bioorganic & Medicinal Chemistry|February 3, 2020
New thiopyrimidine-benzenesulfonamide conjugates as selective carbonic anhydrase II inhibitors: synthesis, in vitro biological evaluation, and molecular docking studiesHeba T Abdel-Mohsen, Ahmed M El Kerdawy, Mohamed A Omar, et al.European Journal of Medicinal Chemistry|November 18, 2016
Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle studyAhmed S Abdelsamie, Chris J van Koppen, Emmanuel Bey, et al.The Journal of Steroid Biochemistry and Molecular Biology|June 12, 2019
Effects of 17β-HSD2 inhibition in bones on osteoporosis based on an animal rat modelSebastian T Müller, Sophie Pählig, Ahmed Merabet, et al.Pageof 3