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Bioorganic & Medicinal Chemistry Letters|December 20, 2008
Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activityKen-ichi Morishita, Nobumasa Yakushiji, Fuminori Ohsawa, et al.ACS Medicinal Chemistry Letters|March 28, 2015
Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonistsToshiki Kobayashi, Yuki Furusawa, Shoya Yamada, et al.Chemmedchem|December 25, 2007
Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype preference: RXRalpha-preferential agonist possessing a sulfonamide moietyKayo Takamatsu, Atsushi Takano, Nobumasa Yakushiji, et al.Journal of Medicinal Chemistry|December 9, 2014
RXR partial agonist produced by side chain repositioning of alkoxy RXR full agonist retains antitype 2 diabetes activity without the adverse effectsKohei Kawata, Ken-ichi Morishita, Mariko Nakayama, et al.Journal of Medicinal Chemistry|February 9, 2013
Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potencyFuminori Ohsawa, Shoya Yamada, Nobumasa Yakushiji, et al.ACS Medicinal Chemistry Letters|June 6, 2014
RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full AgonistsHiroki Kakuta, Nobumasa Yakushiji, Ryosuke Shinozaki, et al.Pageof 9