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Toxicon : Official Journal of the International Society on Toxinology|August 1, 2016
Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) poreEvelyn Martínez-Morales, Ivan Kopljar, Jon D Rainier, et al.
The Journal of General Physiology|February 13, 2013
The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting stateIvan Kopljar, Alain J Labro, Tessa de Block, et al.
The Journal of Biological Chemistry|September 1, 2009
Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channelsElke Bocksteins, Alain J Labro, Evy Mayeur, et al.
Neuropharmacology|March 10, 2016
Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channelsIvan Kopljar, Alessandro Grottesi, Tessa de Block, et al.
The Journal of General Physiology|November 26, 2008
Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residuesAlain J Labro, Adam L Raes, Alessandro Grottesi, et al.
International Journal of Molecular Sciences|December 24, 2021
Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-κB SignalingRohit Arora, Kenny M Van Theemsche, Samuel Van Remoortel, et al.
Pharmaceuticals (Basel, Switzerland)|December 23, 2022
A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5Szilvia Déri, Teodóra Hartai, László Virág, et al.
Proceedings of the National Academy of Sciences of the United States of America|June 2, 2009
A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierolIvan Kopljar, Alain J Labro, Eva Cuypers, et al.
Biophysical Journal|August 18, 2010
Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channelNicolas Rodriguez, Mohamed Yassine Amarouch, Jérôme Montnach, et al.
Journal of Pharmacological and Toxicological Methods|October 2, 2024
Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channelKenny M Van Theemsche, Lisse Frans, Dieter V Van de Sande, et al.
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