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Biochemistry
|
April 28, 2007
Structure of the catalytic domain of human polo-like kinase 1
Michael Kothe, Darcy Kohls, Simon Low, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 18, 2007
N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR
Holly L Deak, John R Newcomb, Joseph J Nunes, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 13, 2010
Enhanced selectivity profile of pyrazole-urea based DFG-out p38alpha inhibitors
Hu Liu, Cyrille Kuhn, Frederic Feru, et al.
Journal of Medicinal Chemistry
|
August 30, 2012
Structure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and CNS penetrable BACE inhibitors for the treatment of Alzheimer's disease
Hongbing Huang, Daniel S La, Alan C Cheng, et al.
Communications Biology
|
July 31, 2023
Structural insights into selective small molecule activation of PKG1α
Essam Metwally, Victor Mak, Aileen Soriano, et al.
Journal of Medicinal Chemistry
|
November 4, 2014
Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718)
Thomas A Dineen, Kui Chen, Alan C Cheng, et al.
ACS Medicinal Chemistry Letters
|
March 18, 2026
<i>N</i>‑Alkyl and <i>N</i>‑Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors
Rohan R Merchant, Natalia Chernyak, Jovan A Lopez, et al.
Frontiers in Immunology
|
May 23, 2022
Hexamerization of Anti-SARS CoV IgG1 Antibodies Improves Neutralization Capacity
Kalyan Pande, Scott A Hollingsworth, Miranda Sam, et al.
Journal of Medicinal Chemistry
|
November 13, 2014
Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors
Oleg Epstein, Marian C Bryan, Alan C Cheng, et al.
Chemical Biology & Drug Design
|
October 22, 2009
The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay
Haile Tecle, Frederic Feru, Hu Liu, et al.
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Search research articles
Search
Showing results (31-40 of 52) with videos related to
Sort By:
Page
of 6
Biochemistry
|
April 28, 2007
Structure of the catalytic domain of human polo-like kinase 1
Michael Kothe, Darcy Kohls, Simon Low, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 18, 2007
N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR
Holly L Deak, John R Newcomb, Joseph J Nunes, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 13, 2010
Enhanced selectivity profile of pyrazole-urea based DFG-out p38alpha inhibitors
Hu Liu, Cyrille Kuhn, Frederic Feru, et al.
Journal of Medicinal Chemistry
|
August 30, 2012
Structure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and CNS penetrable BACE inhibitors for the treatment of Alzheimer's disease
Hongbing Huang, Daniel S La, Alan C Cheng, et al.
Communications Biology
|
July 31, 2023
Structural insights into selective small molecule activation of PKG1α
Essam Metwally, Victor Mak, Aileen Soriano, et al.
Journal of Medicinal Chemistry
|
November 4, 2014
Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718)
Thomas A Dineen, Kui Chen, Alan C Cheng, et al.
ACS Medicinal Chemistry Letters
|
March 18, 2026
<i>N</i>‑Alkyl and <i>N</i>‑Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors
Rohan R Merchant, Natalia Chernyak, Jovan A Lopez, et al.
Frontiers in Immunology
|
May 23, 2022
Hexamerization of Anti-SARS CoV IgG1 Antibodies Improves Neutralization Capacity
Kalyan Pande, Scott A Hollingsworth, Miranda Sam, et al.
Journal of Medicinal Chemistry
|
November 13, 2014
Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors
Oleg Epstein, Marian C Bryan, Alan C Cheng, et al.
Chemical Biology & Drug Design
|
October 22, 2009
The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay
Haile Tecle, Frederic Feru, Hu Liu, et al.
Page
of 6