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Biochemical Pharmacology|July 28, 2024
The ester-containing prodrug NT-0796 enhances delivery of the NLRP3 inflammasome inhibitor NDT-19795 to monocytic cells expressing carboxylesterase-1John R Doedens, Christine Diamond, David Harrison, et al.
ACS Chemical Neuroscience|January 26, 2026
Ester Prodrug NLRP3 Inflammasome Inhibitor NT-0796 is Brain Active due to Activation by Local Expression of Carboxylesterase-1Zsofia Digby, Christine Diamond, Heather Wescott, et al.
Movement Disorders : Official Journal of the Movement Disorder Society|August 12, 2025
Anti-Neuroinflammatory and Anti-Inflammatory Effects of the NLRP3 Inhibitor NT-0796 in Subjects with Parkinson's DiseaseNicholas Clarke, Peter Thornton, Valérie Reader, et al.
ACS Pharmacology & Translational Science|May 16, 2024
Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1H-pyrazol-4-yl)({[(2S)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational FrameworkJohn R Doedens, Pamela Smolak, MyTrang Nguyen, et al.
Journal of Attention Disorders|November 18, 2011
A randomized, double-blind, crossover comparison of MK-0929 and placebo in the treatment of adults with ADHDAnna Rivkin, Robert C Alexander, Jennifer Knighton, et al.
Journal of Medicinal Chemistry|October 24, 2023
Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory DisordersDavid Harrison, Andy Billinton, Mark G Bock, et al.
Biopharmaceutics & Drug Disposition|June 16, 2007
Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligandsAndrew Pike, Susan M Cook, Alan P Watt, et al.
The Journal of Pharmacology and Experimental Therapeutics|January 22, 2024
Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances PotencyPamela Smolak, MyTrang Nguyen, Christine Diamond, et al.
ACS Medicinal Chemistry Letters|August 18, 2022
Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome InhibitorsDavid Harrison, Mark G Bock, John R Doedens, et al.
RSC Medicinal Chemistry|September 8, 2025
Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an in vivo tool compound for neuroinflammatory disordersDavid Harrison, Andy Billinton, Mark G Bock, et al.
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