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Bioorganic & Medicinal Chemistry
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June 4, 2014
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents
Xin Zhang, Sudhir Raghavan, Michael Ihnat, et al.
Molecular Pharmacology
|
July 24, 2024
Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates
Carrie O'Connor, Mathew Schneider, Jade M Katinas, et al.
Journal of Medicinal Chemistry
|
August 15, 2023
Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria
Md Junayed Nayeen, Jade M Katinas, Tejashree Magdum, et al.
Journal of Medicinal Chemistry
|
September 2, 2011
Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase
Lei Wang, Sita Kugel Desmoulin, Christina Cherian, et al.
Scientific Reports
|
July 5, 2022
Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment
Adrianne Wallace-Povirk, Lisa Rubinsak, Agnes Malysa, et al.
Biochemistry
|
February 7, 2024
Structural Characterization of 5-Substituted Pyrrolo[3,2-<i>d</i>]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2
Jade M Katinas, Md Junayed Nayeen, Mathew Schneider, et al.
ACS Pharmacology & Translational Science
|
May 18, 2023
Multitargeted 6-Substituted Thieno[2,3-<i>d</i>]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism
Nian Tong, Jennifer Wong-Roushar, Adrianne Wallace-Povirk, et al.
Journal of Medicinal Chemistry
|
August 29, 2015
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors
Lei Wang, Adrianne Wallace, Sudhir Raghavan, et al.
Molecular Cancer Therapeutics
|
February 20, 2024
Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, et al.
Journal of Medicinal Chemistry
|
July 27, 2016
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis
Lalit K Golani, Adrianne Wallace-Povirk, Siobhan M Deis, et al.
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Search research articles
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Showing results (121-130 of 132) with videos related to
Sort By:
Page
of 14
Bioorganic & Medicinal Chemistry
|
June 4, 2014
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents
Xin Zhang, Sudhir Raghavan, Michael Ihnat, et al.
Molecular Pharmacology
|
July 24, 2024
Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates
Carrie O'Connor, Mathew Schneider, Jade M Katinas, et al.
Journal of Medicinal Chemistry
|
August 15, 2023
Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria
Md Junayed Nayeen, Jade M Katinas, Tejashree Magdum, et al.
Journal of Medicinal Chemistry
|
September 2, 2011
Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase
Lei Wang, Sita Kugel Desmoulin, Christina Cherian, et al.
Scientific Reports
|
July 5, 2022
Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment
Adrianne Wallace-Povirk, Lisa Rubinsak, Agnes Malysa, et al.
Biochemistry
|
February 7, 2024
Structural Characterization of 5-Substituted Pyrrolo[3,2-<i>d</i>]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2
Jade M Katinas, Md Junayed Nayeen, Mathew Schneider, et al.
ACS Pharmacology & Translational Science
|
May 18, 2023
Multitargeted 6-Substituted Thieno[2,3-<i>d</i>]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism
Nian Tong, Jennifer Wong-Roushar, Adrianne Wallace-Povirk, et al.
Journal of Medicinal Chemistry
|
August 29, 2015
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors
Lei Wang, Adrianne Wallace, Sudhir Raghavan, et al.
Molecular Cancer Therapeutics
|
February 20, 2024
Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, et al.
Journal of Medicinal Chemistry
|
July 27, 2016
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis
Lalit K Golani, Adrianne Wallace-Povirk, Siobhan M Deis, et al.
Page
of 14