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Journal of Medicinal Chemistry
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October 31, 2003
Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents
Aleem Gangjee, Ona O Adair, Sherry F Queener
Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
|
August 5, 2009
The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex
Vivian Cody, Jim Pace, Lu Lin, et al.
Expert Opinion on Drug Metabolism & Toxicology
|
October 14, 2022
Biology and therapeutic applications of the proton-coupled folate transporter
Larry H Matherly, Mathew Schneider, Aleem Gangjee, et al.
Acta Crystallographica. Section D, Biological Crystallography
|
August 20, 2003
Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase
Vivian Cody, Joseph R Luft, Walter Pangborn, et al.
Acta Crystallographica. Section F, Structural Biology Communications
|
June 10, 2015
Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase
Vivian Cody, Jim Pace, Ojas A Namjoshi, et al.
Journal of Medicinal Chemistry
|
September 20, 2008
Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine antifolates
Aleem Gangjee, Yibin Qiu, Wei Li, et al.
Current Medicinal Chemistry. Anti-Cancer Agents
|
April 8, 2003
Recent advances in the chemistry and biology of folypoly-gamma-glutamate synthetase substrates and inhibitors
Aleem Gangjee, Nauzer P Dubash, Yibin Zeng, et al.
Bioorganic & Medicinal Chemistry
|
November 8, 2003
Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases
Aleem Gangjee, Jie Yang, Michael A Ihnat, et al.
Journal of Medicinal Chemistry
|
December 13, 2007
Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors
Aleem Gangjee, Wei Li, Jie Yang, et al.
Acta Crystallographica. Section D, Biological Crystallography
|
December 3, 2010
Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase
Vivian Cody, Jennifer Piraino, Jim Pace, et al.
Page
of 14
Search research articles
Search
Showing results (11-20 of 132) with videos related to
Sort By:
Page
of 14
Journal of Medicinal Chemistry
|
October 31, 2003
Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents
Aleem Gangjee, Ona O Adair, Sherry F Queener
Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
|
August 5, 2009
The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex
Vivian Cody, Jim Pace, Lu Lin, et al.
Expert Opinion on Drug Metabolism & Toxicology
|
October 14, 2022
Biology and therapeutic applications of the proton-coupled folate transporter
Larry H Matherly, Mathew Schneider, Aleem Gangjee, et al.
Acta Crystallographica. Section D, Biological Crystallography
|
August 20, 2003
Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase
Vivian Cody, Joseph R Luft, Walter Pangborn, et al.
Acta Crystallographica. Section F, Structural Biology Communications
|
June 10, 2015
Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase
Vivian Cody, Jim Pace, Ojas A Namjoshi, et al.
Journal of Medicinal Chemistry
|
September 20, 2008
Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine antifolates
Aleem Gangjee, Yibin Qiu, Wei Li, et al.
Current Medicinal Chemistry. Anti-Cancer Agents
|
April 8, 2003
Recent advances in the chemistry and biology of folypoly-gamma-glutamate synthetase substrates and inhibitors
Aleem Gangjee, Nauzer P Dubash, Yibin Zeng, et al.
Bioorganic & Medicinal Chemistry
|
November 8, 2003
Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases
Aleem Gangjee, Jie Yang, Michael A Ihnat, et al.
Journal of Medicinal Chemistry
|
December 13, 2007
Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors
Aleem Gangjee, Wei Li, Jie Yang, et al.
Acta Crystallographica. Section D, Biological Crystallography
|
December 3, 2010
Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase
Vivian Cody, Jennifer Piraino, Jim Pace, et al.
Page
of 14