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Diabetes, Obesity & Metabolism|August 20, 2025
Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001Yusman Manchanda, Ben Jones, Gaelle Carrat, et al.
Biorxiv : the Preprint Server for Biology|January 27, 2025
Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion <i>in vitro</i> and <i>in vivo</i> of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001Yusman Manchanda, Ben Jones, Gaelle Carrat, et al.
Cell Reports|March 27, 2024
OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretionStyliani Panagiotou, Kia Wee Tan, Phuoc My Nguyen, et al.
Chemical Science|February 5, 2020
Ureidopeptide GLP-1 analogues with prolonged activity <i>in vivo via</i> signal bias and altered receptor traffickingJuliette Fremaux, Claire Venin, Laura Mauran, et al.
Science Signaling|July 2, 2024
Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signalingYusman Manchanda, Liliane ElEid, Affiong I Oqua, et al.
Diabetes, Obesity & Metabolism|April 3, 2025
Oppositely biased glucagon-like peptide-1 receptor agonism does not differentially affect lipid metabolism in APOE*3-Leiden CETP miceMelanie Modder, Alejandra Tomas, Salwa Afkir, et al.
Nature Communications|May 17, 2019
Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitroSamuel A Watson, James Duff, Ifigeneia Bardi, et al.
Elife|April 24, 2025
Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cellsAffiong Ika Oqua, Kin Chao, Liliane El Eid, et al.
British Journal of Pharmacology|May 22, 2020
Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatidePhilip Pickford, Maria Lucey, Zijian Fang, et al.
Molecular Pharmacology|July 28, 2021
Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and TraffickingMaria Lucey, Tanyel Ashik, Amaara Marzook, et al.
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