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Bioorganic & Medicinal Chemistry Letters|January 18, 2006
Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis modelWendy B Young, Joyce Mordenti, Steven Torkelson, et al.Bioorganic & Medicinal Chemistry Letters|December 26, 2012
Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinaseSteven T Staben, Nicole Blaquiere, Vickie Tsui, et al.ACS Medicinal Chemistry Letters|March 19, 2020
Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo ActivityNaomi S Rajapaksa, Alberto Gobbi, Joy Drobnick, et al.Journal of Medicinal Chemistry|May 15, 2019
Development of Potent and Selective Pyrazolopyrimidine IRAK4 InhibitorsMarian C Bryan, Joy Drobnick, Alberto Gobbi, et al.Bioorganic & Medicinal Chemistry Letters|April 27, 2023
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug designJames J Crawford, Jianwen Feng, Hans D Brightbill, et al.Journal of Medicinal Chemistry|May 14, 2013
Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activityChudi O Ndubaku, Timothy P Heffron, Steven T Staben, et al.Journal of Medicinal Chemistry|March 30, 2018
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular ModelingHuifen Chen, Matthew Volgraf, Steven Do, et al.Journal of Medicinal Chemistry|February 5, 2019
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple MyelomaXiaojing Wang, Wesley Blackaby, Vivienne Allen, et al.Bioorganic & Medicinal Chemistry Letters|July 17, 2019
Design of a brain-penetrant CDK4/6 inhibitor for glioblastomaSarah M Bronner, Karl A Merrick, Jeremy Murray, et al.Pageof 2