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Nature Communications|October 10, 2022
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivoChristiane Kofink, Nicole Trainor, Barbara Mair, et al.EMBO Reports|June 8, 2017
Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specificationRosalia Fernandez-Alonso, Lindsay Davidson, Jens Hukelmann, et al.Journal of Medicinal Chemistry|August 13, 2021
Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H)Tatsuki Koike, Masato Yoshikawa, Haruhi Kamisaki Ando, et al.Nature Communications|October 10, 2023
Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, et al.The Journal of Biological Chemistry|December 16, 2014
Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2)Emil Bulatov, Esther M Martin, Sneha Chatterjee, et al.ACS Medicinal Chemistry Letters|September 17, 2020
Understanding and Improving the Membrane Permeability of VH032-Based PROTACsVictoria G Klein, Chad E Townsend, Andrea Testa, et al.Nature Chemical Biology|November 4, 2022
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degradersAlexander Hanzl, Ryan Casement, Hana Imrichova, et al.Journal of Medicinal Chemistry|October 15, 2021
Development of BromoTag: A "Bump-and-Hole"-PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target ProteinsAdam G Bond, Conner Craigon, Kwok-Ho Chan, et al.Journal of the American Chemical Society|February 29, 2012
Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interactionDennis L Buckley, Inge Van Molle, Peter C Gareiss, et al.Journal of Medicinal Chemistry|December 13, 2018
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7Vittoria Zoppi, Scott J Hughes, Chiara Maniaci, et al.Pageof 16