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Journal of the American Chemical Society|August 25, 2022
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2Xingui Liu, Alexia F Kalogeropulou, Sofia Domingos, et al.Cell Chemical Biology|January 4, 2025
The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cellsGernot Wolf, Conner Craigon, Shao Thing Teoh, et al.Exploration of Targeted Anti-Tumor Therapy|September 1, 2022
The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like typeChiara Tarantelli, Eleonora Cannas, Hillarie Ekeh, et al.Journal of the American Chemical Society|June 28, 2018
3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein DegradationAndrea Testa, Xavier Lucas, Guilherme V Castro, et al.Science (New York, N.Y.)|October 18, 2014
Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probesMatthias G J Baud, Enrique Lin-Shiao, Teresa Cardote, et al.Nature Communications|October 6, 2025
Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screeningAndreas Holmqvist, Nur Mehpare Kocaturk, Christina Duncan, et al.Nature Chemical Biology|June 11, 2019
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC designWilliam Farnaby, Manfred Koegl, Michael J Roy, et al.Nature Chemical Biology|July 4, 2019
Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC designWilliam Farnaby, Manfred Koegl, Michael J Roy, et al.Leukemia|March 12, 2025
Loss of Socs2 improves molecular responses to IFNα in a mouse model of myeloproliferative neoplasms driven by JAK2-V617FMarc Usart, Quentin Kimmerlin, Jan Stetka, et al.Nature Communications|November 5, 2016
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibitionJulianty Frost, Carles Galdeano, Pedro Soares, et al.Pageof 16