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Journal of Medicinal Chemistry|October 27, 2022
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C InhibitorJoachim Bröker, Alex G Waterson, Chris Smethurst, et al.Journal of Medicinal Chemistry|September 12, 2018
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RASTimothy R Hodges, Jason R Abbott, Andrew J Little, et al.Journal of Medicinal Chemistry|July 25, 2025
Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo EfficacyJoachim Bröker, Alex G Waterson, Timothy R Hodges, et al.Nature Communications|April 14, 2025
Drugit: crowd-sourcing molecular design of non-peptidic VHL bindersThomas Scott, Christian Alan Paul Smethurst, Yvonne Westermaier, et al.Antimicrobial Agents and Chemotherapy|September 13, 2021
Simultaneous Exposure to Intracellular and Extracellular Photosensitizers for the Treatment of Staphylococcus aureus InfectionsSydney L Drury, Anderson R Miller, Clare L Laut, et al.Journal of Medicinal Chemistry|November 15, 2019
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein InteractionJonathan D Macdonald, Selena Chacón Simon, Changho Han, et al.Bioorganic & Medicinal Chemistry Letters|March 27, 2021
Optimization of ether and aniline based inhibitors of lactate dehydrogenasePlamen P Christov, Kwangho Kim, Somnath Jana, et al.Bioorganic & Medicinal Chemistry Letters|November 26, 2008
Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines as EGFR and ErbB-2 inhibitorsKirk L Stevens, Krystal J Alligood, Jennifer G Badiang Alberti, et al.Journal of Medicinal Chemistry|March 30, 2026
Identification of KLHL12 Ligands Using Fragment-Based MethodsAlex G Waterson, Anish Vadukoot, Somnath Jana, et al.Proceedings of the National Academy of Sciences of the United States of America|February 22, 2008
6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinasesEdgar R Wood, Lisa M Shewchuk, Byron Ellis, et al.Pageof 7