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Chemmedchem|May 15, 2013
The lab oddity prevails: discovery of pan-CDK inhibitor (R)-S-cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the treatment of cancerUlrich Lücking, Rolf Jautelat, Martin Krüger, et al.Journal of Medicinal Chemistry|October 27, 2020
Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral PharmacokineticsAlexander Hillisch, Kersten M Gericke, Swen Allerheiligen, et al.The Journal of Biological Chemistry|July 24, 2015
Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1Larbi Amazit, Florian Le Billan, Peter Kolkhof, et al.Chemmedchem|July 14, 2012
Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseasesLars Bärfacker, Alexander Kuhl, Alexander Hillisch, et al.Nature Structural & Molecular Biology|June 19, 2024
Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsantsAnshumali Mittal, Matthew F Martin, Elena J Levin, et al.Journal of Medicinal Chemistry|September 5, 2023
Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic DisordersSusanne Roehrig, Jens Ackerstaff, Eloísa Jiménez Núñez, et al.Journal of Medicinal Chemistry|May 27, 2020
Structure-Permeability Relationship of Semipeptidic Macrocycles-Understanding and Optimizing Passive Permeability and Efflux RatioAntoine Le Roux, Émilie Blaise, Pierre-Luc Boudreault, et al.Journal of Medicinal Chemistry|June 11, 2025
Discovery of BAY 3389934 Hydrochloride: A Potent and Selective Small-Molecule Dual Factor IIa/Xa Inhibitor with Short Half-Life for the Acute Treatment of Sepsis-Induced CoagulopathyHartmut Beck, Stefanie Mesch, Stefanie Zimmermann, et al.Nature Reviews. Chemistry|July 5, 2022
CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-findingSuzanne Ackloo, Rima Al-Awar, Rommie E Amaro, et al.RSC Medicinal Chemistry|June 26, 2023
Target 2035 - an update on private sector contributionsSuzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, et al.Pageof 5