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Alexander Pasternak

Showing results (31-40 of 46) with videos related to

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ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism DiureticsHaifeng Tang, Shawn P Walsh, Yan Yan, et al.
SLAS Discovery : Advancing Life Sciences R & D|August 27, 2020
Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 InhibitorsBrian M Lacey, Zangwei Xu, Xiaomei Chai, et al.
Journal of Medicinal Chemistry|May 26, 2021
Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/NatriureticJinlong Jiang, Fa-Xiang Ding, Xiaoyan Zhou, et al.
Bioorganic & Medicinal Chemistry Letters|March 28, 2016
Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporationShawn P Walsh, Aurash Shahripour, Haifeng Tang, et al.
Bioorganic & Medicinal Chemistry Letters|April 23, 2017
Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophoresShuzhi Dong, Kelsey VanGelder, Zhi-Cai Shi, et al.
ACS Medicinal Chemistry Letters|July 21, 2016
Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart FailureHaifeng Tang, Yuping Zhu, Nardos Teumelsan, et al.
Bioorganic & Medicinal Chemistry Letters|October 13, 2024
Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issuesFrank Bennett, Yuhua Huang, Shuzhi Dong, et al.
Bioorganic & Medicinal Chemistry Letters|November 15, 2016
Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffoldYuping Zhu, Reynalda K de Jesus, Haifeng Tang, et al.
Journal of Medicinal Chemistry|March 3, 2022
Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral DosingDerun Li, David L Sloman, Abdelghani Achab, et al.
ACS Medicinal Chemistry Letters|July 21, 2015
Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical EvaluationShawn P Walsh, Aurash Shahripour, Haifeng Tang, et al.
Pageof 5

Showing results (31-40 of 46) with videos related to

Sort By:
Pageof 5
ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism DiureticsHaifeng Tang, Shawn P Walsh, Yan Yan, et al.
SLAS Discovery : Advancing Life Sciences R & D|August 27, 2020
Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 InhibitorsBrian M Lacey, Zangwei Xu, Xiaomei Chai, et al.
Journal of Medicinal Chemistry|May 26, 2021
Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/NatriureticJinlong Jiang, Fa-Xiang Ding, Xiaoyan Zhou, et al.
Bioorganic & Medicinal Chemistry Letters|March 28, 2016
Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporationShawn P Walsh, Aurash Shahripour, Haifeng Tang, et al.
Bioorganic & Medicinal Chemistry Letters|April 23, 2017
Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophoresShuzhi Dong, Kelsey VanGelder, Zhi-Cai Shi, et al.
ACS Medicinal Chemistry Letters|July 21, 2016
Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart FailureHaifeng Tang, Yuping Zhu, Nardos Teumelsan, et al.
Bioorganic & Medicinal Chemistry Letters|October 13, 2024
Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issuesFrank Bennett, Yuhua Huang, Shuzhi Dong, et al.
Bioorganic & Medicinal Chemistry Letters|November 15, 2016
Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffoldYuping Zhu, Reynalda K de Jesus, Haifeng Tang, et al.
Journal of Medicinal Chemistry|March 3, 2022
Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral DosingDerun Li, David L Sloman, Abdelghani Achab, et al.
ACS Medicinal Chemistry Letters|July 21, 2015
Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical EvaluationShawn P Walsh, Aurash Shahripour, Haifeng Tang, et al.
Pageof 5