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Journal of Medicinal Chemistry|August 16, 2022
Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial InfectionsNatalie Hawryluk, Dale Robinson, Yixing Shen, et al.Plos Neglected Tropical Diseases|December 7, 2020
Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infectionsAndrea Schiefer, Marc P Hübner, Anna Krome, et al.International Journal for Parasitology. Drugs and Drug Resistance|July 14, 2022
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimizationNatalie Hawryluk, Li Zhiru, Clotilde Carlow, et al.Plos Neglected Tropical Diseases|January 28, 2020
In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontisAlexandra Ehrens, Christopher S Lunde, Robert T Jacobs, et al.Plos One|June 2, 2023
The design and development of a study protocol to investigate Onchocerca volvulus, Loa loa and Mansonella perstans-mediated modulation of the metabolic and immunological profile in lean and obese individuals in CameroonBenjamin Lenz, Beng Amuam Andrew, Manuel Ritter, et al.Frontiers in Microbiology|February 16, 2024
Combinations of the azaquinazoline anti-<i>Wolbachia</i> agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasisShrilakshmi Hegde, Amy E Marriott, Nicolas Pionnier, et al.Plos Neglected Tropical Diseases|March 1, 2019
Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activityThomas W von Geldern, Howard E Morton, Rick F Clark, et al.International Journal for Parasitology. Drugs and Drug Resistance|December 24, 2019
Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird modelsMarc P Hübner, Emma Gunderson, Ian Vogel, et al.Journal of Medicinal Chemistry|February 8, 2019
Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic FilariasisRobert T Jacobs, Christopher S Lunde, Yvonne R Freund, et al.Science Translational Medicine|March 15, 2019
Preclinical development of an oral anti-<i>Wolbachia</i> macrolide drug for the treatment of lymphatic filariasis and onchocerciasisMark J Taylor, Thomas W von Geldern, Louise Ford, et al.Pageof 4