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RSC Medicinal Chemistry
|
May 28, 2021
Shifting the paradigm in treating multi-factorial diseases: polypharmacological co-inhibitors of HDAC6
Alexandria M Chan, Steven Fletcher
Drug Development Research
|
October 25, 2022
1-Sulfonylated 1,2,3,4-tetrahydroquinoline-6-carboxylic acids as simple, readily-accessible MCL-1 inhibitors
Lijia Chen, Alexandria M Chan, Paul T Wilder, et al.
RSC Medicinal Chemistry
|
September 12, 2022
Recent applications of covalent chemistries in protein-protein interaction inhibitors
Alexandria M Chan, Christopher C Goodis, Elie G Pommier, et al.
Bioorganic & Medicinal Chemistry
|
April 6, 2024
Histone deacetylase (HDAC) inhibitor specificity determinants are preserved in a class of dual HDAC/non-covalent proteasome inhibitors
Alexandria M Chan, Ashley Mitchell, Lena Grogan, et al.
Drug Development Research
|
May 15, 2025
Augmenting the Anti-Leukemic Activity of the BCL-2 Inhibitor Venetoclax Through Its Transformation Into Polypharmacologic Dual BCL-2/HDAC1 and Dual BCL-2/HDAC6 Inhibitors
Alexandria M Chan, Christian Eberly, Brandon Drennen, et al.
European Journal of Medicinal Chemistry
|
January 15, 2025
The polypharmacy combination of the BCL-2 inhibitor venetoclax (VEN) and the FLT3 inhibitor gilteritinib (GIL) is more active in acute myeloid leukemia cells than novel polypharmacologic BCL-2/FLT3 VEN-GIL hybrid single-molecule inhibitors
Christopher C Goodis, Christian Eberly, Alexandria M Chan, et al.
Journal of Proteome Research
|
August 27, 2025
diaPASEF-Powered Chemoproteomics Enables Deep Kinome Interaction Profiling
Kathryn Woods, Alexandria M Chan, Thankhoe A Rants'o, et al.
Biorxiv : the Preprint Server for Biology
|
November 28, 2024
diaPASEF-Powered Chemoproteomics Enables Deep Kinome Interaction Profiling
Kathryn Woods, Thankhoe A Rants'o, Alexandria M Chan, et al.
ACS Medicinal Chemistry Letters
|
January 14, 2026
First-in-Class Potent, Dual HDAC6/Proteasome Inhibitors Lacking a Hydroxamic Acid Motif: Discovery of Novel Anti-Multiple Myeloma Agents
Alexandria M Chan, Brandon D Lowe, Andrea L Cottingham, et al.
Cells
|
January 9, 2026
Multiomic Analyses Reveal Brainstem Metabolic Changes in a Mouse Model of Dravet Syndrome
Ashwini Sri Hari, Alexandria M Chan, Audrey Scholl, et al.
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Showing results (1-10 of 10) with videos related to
Sort By:
Page
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RSC Medicinal Chemistry
|
May 28, 2021
Shifting the paradigm in treating multi-factorial diseases: polypharmacological co-inhibitors of HDAC6
Alexandria M Chan, Steven Fletcher
Drug Development Research
|
October 25, 2022
1-Sulfonylated 1,2,3,4-tetrahydroquinoline-6-carboxylic acids as simple, readily-accessible MCL-1 inhibitors
Lijia Chen, Alexandria M Chan, Paul T Wilder, et al.
RSC Medicinal Chemistry
|
September 12, 2022
Recent applications of covalent chemistries in protein-protein interaction inhibitors
Alexandria M Chan, Christopher C Goodis, Elie G Pommier, et al.
Bioorganic & Medicinal Chemistry
|
April 6, 2024
Histone deacetylase (HDAC) inhibitor specificity determinants are preserved in a class of dual HDAC/non-covalent proteasome inhibitors
Alexandria M Chan, Ashley Mitchell, Lena Grogan, et al.
Drug Development Research
|
May 15, 2025
Augmenting the Anti-Leukemic Activity of the BCL-2 Inhibitor Venetoclax Through Its Transformation Into Polypharmacologic Dual BCL-2/HDAC1 and Dual BCL-2/HDAC6 Inhibitors
Alexandria M Chan, Christian Eberly, Brandon Drennen, et al.
European Journal of Medicinal Chemistry
|
January 15, 2025
The polypharmacy combination of the BCL-2 inhibitor venetoclax (VEN) and the FLT3 inhibitor gilteritinib (GIL) is more active in acute myeloid leukemia cells than novel polypharmacologic BCL-2/FLT3 VEN-GIL hybrid single-molecule inhibitors
Christopher C Goodis, Christian Eberly, Alexandria M Chan, et al.
Journal of Proteome Research
|
August 27, 2025
diaPASEF-Powered Chemoproteomics Enables Deep Kinome Interaction Profiling
Kathryn Woods, Alexandria M Chan, Thankhoe A Rants'o, et al.
Biorxiv : the Preprint Server for Biology
|
November 28, 2024
diaPASEF-Powered Chemoproteomics Enables Deep Kinome Interaction Profiling
Kathryn Woods, Thankhoe A Rants'o, Alexandria M Chan, et al.
ACS Medicinal Chemistry Letters
|
January 14, 2026
First-in-Class Potent, Dual HDAC6/Proteasome Inhibitors Lacking a Hydroxamic Acid Motif: Discovery of Novel Anti-Multiple Myeloma Agents
Alexandria M Chan, Brandon D Lowe, Andrea L Cottingham, et al.
Cells
|
January 9, 2026
Multiomic Analyses Reveal Brainstem Metabolic Changes in a Mouse Model of Dravet Syndrome
Ashwini Sri Hari, Alexandria M Chan, Audrey Scholl, et al.
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