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Nature Communications|June 8, 2021
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearanceLaura Ramos Garcia, Tencho Tenev, Richard Newman, et al.The European Respiratory Journal|December 22, 2022
RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPDHannelore P Van Eeckhoutte, Chantal Donovan, Richard Y Kim, et al.Cancer Cell|November 14, 2018
RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic CancerWei Wang, Jill M Marinis, Allison M Beal, et al.Journal of Medicinal Chemistry|July 3, 2019
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory DiseasesPamela A Haile, Linda N Casillas, Bartholomew J Votta, et al.Journal of Medicinal Chemistry|April 26, 2016
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 KinasePamela A Haile, Bartholomew J Votta, Robert W Marquis, et al.Journal of Medicinal Chemistry|April 24, 2019
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) KinasePhilip A Harris, Nicolas Faucher, Nicolas George, et al.Pageof 2