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The AAPS Journal|January 8, 2021
The Role of Alcohol Dehydrogenase in Drug Metabolism: Beyond Ethanol OxidationLi Di, Amanda Balesano, Samantha Jordan, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|October 30, 2025
Human cytochrome P4502C8 metabolizes repaglinide to 4'-hydroxyrepaglinide, not 3'-hydroxyrepaglinideRaman Sharma, Amanda Balesano, Angela C Doran, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 1, 2022
An improved method for cytochrome p450 reaction phenotyping using a sequential qualitative-then-quantitative approachAngela C Doran, Alyssa L Dantonio, Gabrielle M Gualtieri, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|May 8, 2024
The Metabolism and Disposition of Brepocitinib in Humans and Characterization of the Formation Mechanism of an Aminopyridine MetaboliteMartin E Dowty, Ruolun Qiu, Alyssa Dantonio, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 1, 2022
Defining the Selectivity of Chemical Inhibitors Used for Cytochrome P450 Reaction Phenotyping: Overcoming Selectivity Limitations with a Six-Parameter Inhibition Curve-Fitting ApproachAngela C Doran, Woodrow Burchett, Connor Landers, et al.Molecular Pharmaceutics|October 9, 2023
The Comparison of Machine Learning and Mechanistic In Vitro-In Vivo Extrapolation Models for the Prediction of Human Intrinsic ClearanceChristopher E Keefer, George Chang, Li Di, et al.Journal of Medicinal Chemistry|November 19, 2024
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948Kevin J Filipski, Luis A Martinez-Alsina, Matthew R Reese, et al.Science Advances|August 30, 2024
Discovery of SARS-CoV-2 papain-like protease (PL<sup>pro</sup>) inhibitors with efficacy in a murine infection modelMichelle R Garnsey, Matthew C Robinson, Luong T Nguyen, et al.Pageof 1