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Journal of Medicinal Chemistry|December 28, 2020
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)Hengmiao Cheng, Suvi T M Orr, Simon Bailey, et al.Neuro-Oncology Advances|December 31, 2025
An innovative virtual fellowship leveraging global and regional mentorship to foster pediatric neuro-oncologists in low/middle-income countriesZeena Salman, Daniel C Moreira, Rahat Ul Ain, et al.Journal of Medicinal Chemistry|March 14, 2017
Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFRSimon Planken, Douglas C Behenna, Sajiv K Nair, et al.Journal of Medicinal Chemistry|January 18, 2014
Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinibQinhua Huang, Ted W Johnson, Simon Bailey, et al.Nature Medicine|November 18, 2023
The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trialLindsay B Kilburn, Dong-Anh Khuong-Quang, Jordan R Hansford, et al.Journal of Neuro-Oncology|September 16, 2019
Diagnostics and treatment of diffuse intrinsic pontine glioma: where do we stand?Fatma E El-Khouly, Sophie E M Veldhuijzen van Zanten, Vicente Santa-Maria Lopez, et al.Neuro-Oncology|November 9, 2025
A Systematic Study of Molecular Diagnosis, Treatment and Prognosis in Infant-Type Hemispheric Glioma): An Individual Patient Data Meta-analysis of 164 patientsLara Chavaz, Aditi Bagchi, Sandeep K Dhanda, et al.Neuro-Oncology|April 5, 2025
Salvage therapies for first relapse of SHH medulloblastoma in early childhoodCraig Erker, Martin Mynarek, Marie Simbozel, et al.Journal of Medicinal Chemistry|January 13, 2016
Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR MutantsHengmiao Cheng, Sajiv K Nair, Brion W Murray, et al.Blood|July 15, 2022
Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemiaRicky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, et al.Pageof 40