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Aging Cell|March 5, 2019
An early-senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro-inflammatory programDaniela Gnani, Stefania Crippa, Lucrezia Della Volpe, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|August 19, 2022
Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCsStefania Crippa, Anastasia Conti, Valentina Vavassori, et al.
Frontiers in Immunology|June 18, 2021
Premature Senescence and Increased Oxidative Stress in the Thymus of Down Syndrome PatientsGenni Enza Marcovecchio, Francesca Ferrua, Elena Fontana, et al.
Cell Stem Cell|March 26, 2019
Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage ResponseGiulia Schiroli, Anastasia Conti, Samuele Ferrari, et al.
Nature Communications|July 28, 2021
Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosisRiccardo Biavasco, Emanuele Lettera, Kety Giannetti, et al.
Cell Reports. Medicine|June 4, 2025
Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cellsAnastasia Conti, Kety Giannetti, Federico Midena, et al.
Cell Reports. Medicine|November 13, 2024
A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cellsLucrezia Della Volpe, Federico Midena, Roberta Vacca, et al.
Cell Stem Cell|October 7, 2022
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cellsSamuele Ferrari, Aurelien Jacob, Daniela Cesana, et al.
The Journal of Experimental Medicine|December 31, 2025
Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell agingEmanuele Lettera, Luca Basso-Ricci, Edoardo Carsana, et al.
Nature Aging|July 1, 2026
Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and agingAlessia Oppezzo, Sara Sepe, Giada Cicio, et al.
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