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Journal of Medicinal Chemistry|February 21, 2012
Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthritisAnthony D William, Angeline C-H Lee, Anders Poulsen, et al.Mbio|May 7, 2015
Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteriaWilfried Moreira, Grace J Y Ngan, Jian Liang Low, et al.Journal of Medicinal Chemistry|December 14, 2011
Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancerAnthony D William, Angeline C-H Lee, Kee Chuan Goh, et al.The Biochemical Journal|May 3, 2014
Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniquesXiaoying Koh-Stenta, Joma Joy, Anders Poulsen, et al.Chempluschem|January 25, 2020
Application of Fragment-Based Drug Discovery against DNA Gyrase BGuo-Ying Chen, Fui Mee Ng, Yih Wan Tan, et al.ACS Infectious Diseases|January 26, 2019
Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) InhibitorsWenhe Zhong, Ann Koay, Anna Ngo, et al.Angewandte Chemie (International Ed. in English)|May 19, 2021
Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors*David Quach, Guanghui Tang, Jothi Anantharajan, et al.Bioorganic & Medicinal Chemistry Letters|February 3, 2009
N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activityHaishan Wang, Niefang Yu, Hongyan Song, et al.European Journal of Medicinal Chemistry|August 21, 2018
Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteriaSoo Yei Ho, Weiling Wang, Fui Mee Ng, et al.Journal of Medicinal Chemistry|June 26, 2015
Discovery and Optimization of a Porcupine InhibitorAthisayamani Jeyaraj Duraiswamy, May Ann Lee, Babita Madan, et al.Pageof 7