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Journal of Pharmacological and Toxicological Methods|May 16, 2019
Drug safety Africa: An overview of safety pharmacology & toxicology in South AfricaBrian D Guth, Anne F Grobler, Kendall S Frazier, et al.Cell Chemical Biology|December 2, 2023
Selective and brain-penetrant HCN1 inhibitors reveal links between synaptic integration, cortical function, and working memoryEva Harde, Markus Hierl, Michael Weber, et al.International Journal of Toxicology|December 21, 2018
A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored ConsortiumEmmanuel Boulay, Matthew M Abernathy, Ray Chui, et al.Journal of Pharmacological and Toxicological Methods|May 10, 2023
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&AsEric I Rossman, Todd A Wisialowski, Hugo M Vargas, et al.Journal of Pharmacological and Toxicological Methods|March 24, 2023
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysisEmmanuel Boulay, Loïs S Miraucourt, Michael K Pugsley, et al.Clinical Pharmacology and Therapeutics|September 1, 2020
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry PerspectiveHugo M Vargas, Michael G Rolf, Todd A Wisialowski, et al.Clinical Pharmacology and Therapeutics|November 12, 2019
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico StrategyZhihua Li, Gary R Mirams, Takashi Yoshinaga, et al.Pageof 3