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Journal of Medicinal Chemistry|September 10, 2021
Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical ProbeSandra Röhm, Benedict-Tilman Berger, Martin Schröder, et al.European Journal of Medicinal Chemistry|April 24, 2023
Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamilyMarcel Rak, Roberta Tesch, Lena M Berger, et al.Journal of Medicinal Chemistry|February 29, 2024
Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase InhibitorsMarcel Rak, Amelie Menge, Roberta Tesch, et al.Journal of Medicinal Chemistry|July 19, 2024
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase InhibitorsJoshua Gerninghaus, Rezart Zhubi, Andreas Krämer, et al.Biorxiv : the Preprint Server for Biology|February 26, 2024
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activityJoshua Gerninghaus, Rezart Zhubi, Andreas Krämer, et al.Bioconjugate Chemistry|September 1, 2023
Structure-Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein ArylationMaëva M Pichon, Dawid Drelinkiewicz, David Lozano, et al.International Journal of Cancer|June 30, 2020
Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinomaXin Zhang, Tim Zegar, Tim Weiser, et al.Journal of Enzyme Inhibition and Medicinal Chemistry|May 21, 2026
In vitro screening of compounds for targeting gastric cancer with Y220C p53 mutation: a molecule combining zinc chelation and a Michael acceptor drives CDKN1 and BBC3 expression to restore a p53-dependent cytotoxicitySimon Nannini, Céline Sieffert, Andrew McGown, et al.Nature Genetics|January 8, 2025
Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutationsJulianne S Funk, Maria Klimovich, Daniel Drangenstein, et al.Journal of Medicinal Chemistry|April 17, 2025
Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader CollapseAnthony K Edmonds, Dimitrios-Ilias Balourdas, Graham P Marsh, et al.Pageof 8