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Andreas Heine

Showing results (11-20 of 134) with videos related to

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Journal of Medicinal Chemistry|June 8, 2017
Paying the Price of Desolvation in Solvent-Exposed Protein Pockets: Impact of Distal Solubilizing Groups on Affinity and Binding Thermodynamics in a Series of Thermolysin InhibitorsJonathan Cramer, Stefan G Krimmer, Andreas Heine, et al.
Angewandte Chemie (International Ed. in English)|May 10, 2005
Metal ions as cofactors for the binding of inhibitors to methionine aminopeptidase: a critical view of the relevance of in vitro metalloenzyme assaysRolf Schiffmann, Andreas Heine, Gerhard Klebe, et al.
Biomolecules|April 2, 2020
The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase IISteffen Glöckner, Khang Ngo, Björn Wagner, et al.
Angewandte Chemie (International Ed. in English)|October 6, 2020
Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK<sub>a</sub> Shifts Mislead Popular Bioisosterism ConceptsMatthias Oebbeke, Christof Siefker, Björn Wagner, et al.
Journal of Molecular Biology|December 13, 2005
High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring groupHolger Steuber, Matthias Zentgraf, Alberto Podjarny, et al.
Acta Crystallographica. Section D, Biological Crystallography|May 7, 2010
Structure and substrate docking of a hydroxy(phenyl)pyruvate reductase from the higher plant Coleus blumei BenthVerena Janiak, Maike Petersen, Matthias Zentgraf, et al.
Chembiochem : a European Journal of Chemical Biology|February 10, 2009
Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGTTina Ritschel, Simone Hoertner, Andreas Heine, et al.
Journal of Medicinal Chemistry|March 20, 2008
Structure-guided design of C2-symmetric HIV-1 protease inhibitors based on a pyrrolidine scaffoldAndreas Blum, Jark Böttcher, Andreas Heine, et al.
Chemmedchem|January 15, 2016
Boosting Affinity by Correct Ligand Preorganization for the S2 Pocket of Thrombin: A Study by Isothermal Titration Calorimetry, Molecular Dynamics, and High-Resolution Crystal StructuresEggert H Rühmann, Melinda Rupp, Michael Betz, et al.
Journal of Medicinal Chemistry|October 22, 2019
Strategies for Late-Stage Optimization: Profiling Thermodynamics by Preorganization and Salt Bridge ShieldingAnna Sandner, Tobias Hüfner-Wulsdorf, Andreas Heine, et al.
Pageof 14

Showing results (11-20 of 134) with videos related to

Sort By:
Pageof 14
Journal of Medicinal Chemistry|June 8, 2017
Paying the Price of Desolvation in Solvent-Exposed Protein Pockets: Impact of Distal Solubilizing Groups on Affinity and Binding Thermodynamics in a Series of Thermolysin InhibitorsJonathan Cramer, Stefan G Krimmer, Andreas Heine, et al.
Angewandte Chemie (International Ed. in English)|May 10, 2005
Metal ions as cofactors for the binding of inhibitors to methionine aminopeptidase: a critical view of the relevance of in vitro metalloenzyme assaysRolf Schiffmann, Andreas Heine, Gerhard Klebe, et al.
Biomolecules|April 2, 2020
The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase IISteffen Glöckner, Khang Ngo, Björn Wagner, et al.
Angewandte Chemie (International Ed. in English)|October 6, 2020
Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK<sub>a</sub> Shifts Mislead Popular Bioisosterism ConceptsMatthias Oebbeke, Christof Siefker, Björn Wagner, et al.
Journal of Molecular Biology|December 13, 2005
High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring groupHolger Steuber, Matthias Zentgraf, Alberto Podjarny, et al.
Acta Crystallographica. Section D, Biological Crystallography|May 7, 2010
Structure and substrate docking of a hydroxy(phenyl)pyruvate reductase from the higher plant Coleus blumei BenthVerena Janiak, Maike Petersen, Matthias Zentgraf, et al.
Chembiochem : a European Journal of Chemical Biology|February 10, 2009
Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGTTina Ritschel, Simone Hoertner, Andreas Heine, et al.
Journal of Medicinal Chemistry|March 20, 2008
Structure-guided design of C2-symmetric HIV-1 protease inhibitors based on a pyrrolidine scaffoldAndreas Blum, Jark Böttcher, Andreas Heine, et al.
Chemmedchem|January 15, 2016
Boosting Affinity by Correct Ligand Preorganization for the S2 Pocket of Thrombin: A Study by Isothermal Titration Calorimetry, Molecular Dynamics, and High-Resolution Crystal StructuresEggert H Rühmann, Melinda Rupp, Michael Betz, et al.
Journal of Medicinal Chemistry|October 22, 2019
Strategies for Late-Stage Optimization: Profiling Thermodynamics by Preorganization and Salt Bridge ShieldingAnna Sandner, Tobias Hüfner-Wulsdorf, Andreas Heine, et al.
Pageof 14