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Antiviral Research|May 18, 2010
Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2'-ethynyl-7-deaza-adenosine triphosphateDerek R Latour, Andreas Jekle, Hassan Javanbakht, et al.Journal of Medicinal Chemistry|April 6, 2019
Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C InfectionGuangyi Wang, Natalia Dyatkina, Marija Prhavc, et al.International Journal of Molecular Sciences|November 25, 2023
Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy ModelsAndreas Jekle, Santosh Kumar Thatikonda, Ruchika Jaisinghani, et al.Journal of Medicinal Chemistry|August 21, 2020
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of <b>AL-611</b> as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis CGuangyi Wang, Natalia Dyatkina, Marija Prhavc, et al.Structure (London, England : 1993)|February 6, 2026
Structural basis for pan-coronavirus inhibition of 3CL proteaseEswar R Reddem, Farhad Forouhar, Cheng Liu, et al.Biochemical and Biophysical Research Communications|April 4, 2021
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster modelKoen Vandyck, Rana Abdelnabi, Kusum Gupta, et al.Journal of Medicinal Chemistry|September 2, 2024
Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASHKoen Vandyck, David C McGowan, Xuan G Luong, et al.Mbio|January 10, 2023
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor <i>In Vitro</i> and Confer Resistance To NirmatrelvirDirk Jochmans, Cheng Liu, Kim Donckers, et al.Bioorganic & Medicinal Chemistry Letters|April 27, 2010
Novel hexahydropyrrolo[3,4-c]pyrrole CCR5 antagonistsDavid M Rotstein, Chris R Melville, Fernando Padilla, et al.Antiviral Research|February 24, 2024
An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patientsYannick Debing, Hannah Vanrusselt, Lars Degrauwe, et al.Pageof 5