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Andrew G Leach

Showing results (1-10 of 84) with videos related to

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Drug Testing and Analysis|December 20, 2013
Predicting the activity and toxicity of new psychoactive substances: a pharmaceutical industry perspectiveAndrew G Leach
Organic & Biomolecular Chemistry|January 22, 2015
A mechanistic proposal for the protodeboronation of neat boronic acids: boronic acid mediated reaction in the solid stateGary Noonan, Andrew G Leach
Journal of Chemical Information and Modeling|May 6, 2011
Quantitatively interpreted enhanced inhibition of cytochrome P450s by heteroaromatic rings containing nitrogenAndrew G Leach, Nathan J Kidley
Organic & Biomolecular Chemistry|August 22, 2003
The mechanism and regioselectivity of the ene reactions of nitroso compounds: a theoretical study of reactivity, regioselectivity, and kinetic isotope effects establishes a stepwise path involving polarized diradical intermediatesAndrew G Leach, K N Houk
Journal of the American Chemical Society|December 12, 2002
The ene reactions of nitroso compounds involve polarized diradical intermediatesAndrew G Leach, K N Houk
Chemical Communications (Cambridge, England)|July 12, 2002
Diels-Alder and ene reactions of singlet oxygen, nitroso compounds and triazolinediones: transition states and mechanisms from contemporary theoryAndrew G Leach, K N Houk
Journal of Medicinal Chemistry|June 19, 2009
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockersUlrich Zachariae, Fabrizio Giordanetto, Andrew G Leach
Molecular Informatics|August 5, 2016
Designing Hydroxamates and Reversed Hydroxamates to Inhibit Zinc-containing Proteases but not Cytochrome P450s: Insights from Quantum Mechanics and Protein-ligand Crystal StructuresCharlotte Barker, Iva Lukac, Andrew G Leach
Chemical Communications (Cambridge, England)|February 20, 2009
Reaction energies computed with density functional theory correspond with a whole organism effect; modelling the Ames test for mutagenicityAndrew G Leach, Rebecca Cann, Simone Tomasi
Journal of Medicinal Chemistry|April 15, 2022
Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative BacteriaDominik Gurvic, Andrew G Leach, Ulrich Zachariae
Pageof 9

Showing results (1-10 of 84) with videos related to

Sort By:
Pageof 9
Drug Testing and Analysis|December 20, 2013
Predicting the activity and toxicity of new psychoactive substances: a pharmaceutical industry perspectiveAndrew G Leach
Organic & Biomolecular Chemistry|January 22, 2015
A mechanistic proposal for the protodeboronation of neat boronic acids: boronic acid mediated reaction in the solid stateGary Noonan, Andrew G Leach
Journal of Chemical Information and Modeling|May 6, 2011
Quantitatively interpreted enhanced inhibition of cytochrome P450s by heteroaromatic rings containing nitrogenAndrew G Leach, Nathan J Kidley
Organic & Biomolecular Chemistry|August 22, 2003
The mechanism and regioselectivity of the ene reactions of nitroso compounds: a theoretical study of reactivity, regioselectivity, and kinetic isotope effects establishes a stepwise path involving polarized diradical intermediatesAndrew G Leach, K N Houk
Journal of the American Chemical Society|December 12, 2002
The ene reactions of nitroso compounds involve polarized diradical intermediatesAndrew G Leach, K N Houk
Chemical Communications (Cambridge, England)|July 12, 2002
Diels-Alder and ene reactions of singlet oxygen, nitroso compounds and triazolinediones: transition states and mechanisms from contemporary theoryAndrew G Leach, K N Houk
Journal of Medicinal Chemistry|June 19, 2009
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockersUlrich Zachariae, Fabrizio Giordanetto, Andrew G Leach
Molecular Informatics|August 5, 2016
Designing Hydroxamates and Reversed Hydroxamates to Inhibit Zinc-containing Proteases but not Cytochrome P450s: Insights from Quantum Mechanics and Protein-ligand Crystal StructuresCharlotte Barker, Iva Lukac, Andrew G Leach
Chemical Communications (Cambridge, England)|February 20, 2009
Reaction energies computed with density functional theory correspond with a whole organism effect; modelling the Ames test for mutagenicityAndrew G Leach, Rebecca Cann, Simone Tomasi
Journal of Medicinal Chemistry|April 15, 2022
Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative BacteriaDominik Gurvic, Andrew G Leach, Ulrich Zachariae
Pageof 9