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Andrew G Leach

Showing results (71-80 of 84) with videos related to

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Journal of the American Chemical Society|January 30, 2003
Mechanism of ene reactions of singlet oxygen. A two-step no-intermediate mechanismDaniel A Singleton, Chao Hang, Michael J Szymanski, et al.
Bioorganic & Medicinal Chemistry Letters|October 15, 2008
Inhibitors of the tyrosine kinase EphB4. Part 2: structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidinesCatherine Bardelle, Tanya Coleman, Darren Cross, et al.
Journal of Medicinal Chemistry|November 17, 2012
Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitorsFrederick W Goldberg, Andrew G Leach, James S Scott, et al.
Journal of Medicinal Chemistry|September 29, 2017
Learning Medicinal Chemistry Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) Rules from Cross-Company Matched Molecular Pairs Analysis (MMPA)Christian Kramer, Attilla Ting, Hao Zheng, et al.
RSC Chemical Biology|January 3, 2022
Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activityNicholas J Cundy, Roseanna K Hare, Tina Tang, et al.
Journal of Pharmaceutical Sciences|December 17, 2020
The Inclusion of a Matrix Metalloproteinase-9 Responsive Sequence in Self-assembled Peptide-based Brain-Targeting Nanoparticles Improves the Efficiency of Nanoparticles Crossing the Blood-Brain Barrier at Elevated MMP-9 LevelsYamir Islam, Parinaz Ehtezazi, Andrew Cashmore, et al.
Bioorganic & Medicinal Chemistry Letters|August 13, 2011
The discovery of benzanilides as c-Met receptor tyrosine kinase inhibitors by a directed screening approachJoanne V Allen, Catherine Bardelle, Kevin Blades, et al.
Journal of Medicinal Chemistry|May 23, 2012
Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinaseRichard A Norman, Anne-Kathrin Schott, David M Andrews, et al.
Bioorganic & Medicinal Chemistry Letters|December 29, 2005
Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocketPeter Ballard, Robert H Bradbury, Craig S Harris, et al.
Journal of Medicinal Chemistry|October 7, 2014
Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonistsJames S Scott, Suzanne S Bowker, Katy J Brocklehurst, et al.
Pageof 9

Showing results (71-80 of 84) with videos related to

Sort By:
Pageof 9
Journal of the American Chemical Society|January 30, 2003
Mechanism of ene reactions of singlet oxygen. A two-step no-intermediate mechanismDaniel A Singleton, Chao Hang, Michael J Szymanski, et al.
Bioorganic & Medicinal Chemistry Letters|October 15, 2008
Inhibitors of the tyrosine kinase EphB4. Part 2: structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidinesCatherine Bardelle, Tanya Coleman, Darren Cross, et al.
Journal of Medicinal Chemistry|November 17, 2012
Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitorsFrederick W Goldberg, Andrew G Leach, James S Scott, et al.
Journal of Medicinal Chemistry|September 29, 2017
Learning Medicinal Chemistry Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) Rules from Cross-Company Matched Molecular Pairs Analysis (MMPA)Christian Kramer, Attilla Ting, Hao Zheng, et al.
RSC Chemical Biology|January 3, 2022
Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activityNicholas J Cundy, Roseanna K Hare, Tina Tang, et al.
Journal of Pharmaceutical Sciences|December 17, 2020
The Inclusion of a Matrix Metalloproteinase-9 Responsive Sequence in Self-assembled Peptide-based Brain-Targeting Nanoparticles Improves the Efficiency of Nanoparticles Crossing the Blood-Brain Barrier at Elevated MMP-9 LevelsYamir Islam, Parinaz Ehtezazi, Andrew Cashmore, et al.
Bioorganic & Medicinal Chemistry Letters|August 13, 2011
The discovery of benzanilides as c-Met receptor tyrosine kinase inhibitors by a directed screening approachJoanne V Allen, Catherine Bardelle, Kevin Blades, et al.
Journal of Medicinal Chemistry|May 23, 2012
Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinaseRichard A Norman, Anne-Kathrin Schott, David M Andrews, et al.
Bioorganic & Medicinal Chemistry Letters|December 29, 2005
Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocketPeter Ballard, Robert H Bradbury, Craig S Harris, et al.
Journal of Medicinal Chemistry|October 7, 2014
Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonistsJames S Scott, Suzanne S Bowker, Katy J Brocklehurst, et al.
Pageof 9