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The Journal of Organic Chemistry|November 1, 2023
Enabling, Decagram-Scale Synthesis of Macrocyclic MCL-1 Inhibitor ABBV-467Patrick B Brady, Bryan K Sorensen, Roberto M Risi, et al.Bioorganic & Medicinal Chemistry Letters|January 20, 2007
An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonistsRajesh R Iyengar, John K Lynch, Mathew M Mulhern, et al.Journal of Medicinal Chemistry|October 27, 2006
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetesZhonghua Pei, Xiaofeng Li, Thomas W von Geldern, et al.Journal of Medicinal Chemistry|March 31, 2006
Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonistsPhilip R Kym, Andrew J Souers, Thomas J Campbell, et al.Bioorganic & Medicinal Chemistry Letters|March 14, 2007
Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activityAndrew S Judd, Andrew J Souers, Dariusz Wodka, et al.Journal of Medicinal Chemistry|January 11, 2008
Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitorGang Zhao, Andrew J Souers, Martin Voorbach, et al.Bioorganic & Medicinal Chemistry Letters|December 26, 2006
Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylaminesAndrew J Souers, Rajesh R Iyengar, Andrew S Judd, et al.Communications Medicine|October 25, 2023
Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patientsJunichiro Yuda, Christine Will, Darren C Phillips, et al.Journal of Medicinal Chemistry|October 27, 2006
Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safetyJohn K Lynch, Jennifer C Freeman, Andrew S Judd, et al.Journal of Medicinal Chemistry|January 24, 2012
Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1Vince S C Yeh, David W A Beno, Sevan Brodjian, et al.Pageof 3