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Birth Defects Research. Part B, Developmental and Reproductive Toxicology|August 19, 2010
Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicityRobert L Clark, William E Gristwood, Richard Lewsley, et al.
Pharmacology Research & Perspectives|October 31, 2015
Interrogating the relationship between rat in vivo tissue distribution and drug property data for >200 structurally unrelated moleculesAndrew W Harrell, Caroline Sychterz, May Y Ho, et al.
Chemical Research in Toxicology|April 15, 2024
Cyanide Trapping of Iminium Ion Reactive Metabolites: Implications for Clinical HepatotoxicityXiusheng Miao, Gordon J Dear, Claire Beaumont, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|November 4, 2004
Formation and protein binding of the acyl glucuronide of a leukotriene B4 antagonist (SB-209247): relation to species differences in hepatotoxicityJane R Kenny, James L Maggs, Justice N A Tettey, et al.
Regulatory Toxicology and Pharmacology : RTP|August 8, 2024
Endeavours made by trade associations, pharmaceutical companies and regulators in the replacement, reduction and refinement of animal experimentation in safety testing of pharmaceuticalsAndrew W Harrell, Kirsty Reid, John Vahle, et al.
Clinical Pharmacokinetics|August 30, 2021
Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral AbsorptionNeil A Miller, Rebecca H Graves, Chris D Edwards, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|February 4, 2020
Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical InvestigationsAarti Patel, Robert Wilson, Andrew W Harrell, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|October 9, 2012
Metabolism and disposition of vilanterol, a long-acting β(2)-adrenoceptor agonist for inhalation use in humansAndrew W Harrell, Sarah K Siederer, Jo Bal, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|October 26, 2019
An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male SubjectsAndrew W Harrell, Robert Wilson, Yau Lun Man, et al.
Chemical Research in Toxicology|August 31, 2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compoundsMelanie Z Sakatis, Melinda J Reese, Andrew W Harrell, et al.
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