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Cancer Research|October 30, 2025
Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C InhibitorsYaakov E Stern, Pompom Ghosh, John Peroza, et al.Journal of Medicinal Chemistry|May 12, 2021
Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)-Quinolones with Single Dose CuresAndrii Monastyrskyi, Fabian Brockmeyer, Alexis N LaCrue, et al.Blood Advances|July 8, 2020
The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cellsKamira Maharaj, John J Powers, Alex Achille, et al.Science (New York, N.Y.)|July 23, 2026
Late-stage functionalization with strain-release warheads enables tunable covalent inhibitionZachary P Shultz, Ansar Lee-Sam, Yun-Pu Chang, et al.Journal of Medicinal Chemistry|January 14, 2026
Structure-Activity and Structure-Degradation Relationship Studies of 2-Amino-6-(benzimidazol-2-ylmethyl)-N9-heteroarylpurines as Potent and Selective CDK12/13 Inhibitors and Cyclin K DegradersThiyagamurthy Pandurangan, Solomon Tadesse Zeleke, Anna Iermolaieva, et al.Journal of Medicinal Chemistry|August 23, 2014
Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of PlasmodiumR Matthew Cross, David L Flanigan, Andrii Monastyrskyi, et al.Cancer Research|September 13, 2023
CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple MyelomaKaren L Burger, Mario R Fernandez, Mark B Meads, et al.Pageof 3