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Drug Metabolism and Disposition: the Biological Fate of Chemicals|December 14, 2021
Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction PhenotypingAlyssa L Dantonio, Angela C Doran, R Scott ObachJournal of Clinical Pharmacology|September 21, 2023
Physiologically Based Pharmacokinetic Modeling of the Drug-Drug Interaction Between CYP3A4 Substrate Glasdegib and Moderate CYP3A4 Inducers in Lieu of a Clinical StudyErnesto Callegari, Susanna Tse, Angela C Doran, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|August 18, 2012
An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrationsAngela C Doran, Sarah M Osgood, Jessica Y Mancuso, et al.Journal of Pharmaceutical Sciences|March 18, 2014
Diphenhydramine has similar interspecies net active influx at the blood-brain barrierChristopher L Shaffer, Sarah M Osgood, Jessica Y Mancuso, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|October 30, 2025
Human cytochrome P4502C8 metabolizes repaglinide to 4'-hydroxyrepaglinide, not 3'-hydroxyrepaglinideRaman Sharma, Amanda Balesano, Angela C Doran, et al.Neuropharmacology|July 28, 2011
Comparative analysis of the neurophysiological profile of group II metabotropic glutamate receptor activators and diazepam: effects on hippocampal and cortical EEG patterns in ratsChester J Siok, Shawn M Cogan, Lauren B Shifflett, et al.Molecular Systems Biology|July 30, 2019
Systems approach reveals photosensitivity and PER2 level as determinants of clock-modulator efficacyDae Wook Kim, Cheng Chang, Xian Chen, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 1, 2022
An improved method for cytochrome p450 reaction phenotyping using a sequential qualitative-then-quantitative approachAngela C Doran, Alyssa L Dantonio, Gabrielle M Gualtieri, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 1, 2022
Defining the Selectivity of Chemical Inhibitors Used for Cytochrome P450 Reaction Phenotyping: Overcoming Selectivity Limitations with a Six-Parameter Inhibition Curve-Fitting ApproachAngela C Doran, Woodrow Burchett, Connor Landers, et al.Journal of Pharmaceutical Sciences|April 3, 2018
Prediction of Human Brain Penetration of P-glycoprotein and Breast Cancer Resistance Protein Substrates Using In Vitro Transporter Studies and Animal ModelsBo Feng, Angela C Doran, Li Di, et al.Pageof 2