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Proceedings of the National Academy of Sciences of the United States of America|September 29, 2021
Structural basis for isoform-specific inhibition of human CTPS1Eric M Lynch, Michael A DiMattia, Steven Albanese, et al.
Cell Reports|March 5, 2013
Structure and ubiquitination-dependent activation of TANK-binding kinase 1Daqi Tu, Zehua Zhu, Alicia Y Zhou, et al.
Journal of Medicinal Chemistry|January 24, 2020
Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 InhibitorJustin A Caravella, Jian Lin, R Bruce Diebold, et al.
Bioorganic & Medicinal Chemistry Letters|February 27, 2019
Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN)Matthew W Martin, David R Lancia, Hongbin Li, et al.
Bioorganic & Medicinal Chemistry Letters|July 16, 2022
Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasisSilvana Leit, Jeremy R Greenwood, Sayan Mondal, et al.
Journal of Medicinal Chemistry|April 29, 2026
Design of Cyclic Vinyl Sulfones as WRN Covalent Inhibitors from Noncovalent BindersJustin A Caravella, Angela V Toms, Nikolay Sitnikov, et al.
Journal of Medicinal Chemistry|July 10, 2023
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279Silvana Leit, Jeremy Greenwood, Samantha Carriero, et al.
The Journal of Experimental Medicine|January 25, 2012
Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibitionOliver Weigert, Andrew A Lane, Liat Bird, et al.
Nature|October 19, 2017
Molecular basis of USP7 inhibition by selective small-molecule inhibitorsAndrew P Turnbull, Stephanos Ioannidis, Wojciech W Krajewski, et al.
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