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The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|February 4, 2011
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPaseAnja Capell, Sabine Liebscher, Katrin Fellerer, et al.
Acta Neuropathologica|March 13, 2014
Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosisJulia K Götzl, Kohji Mori, Markus Damme, et al.
Cell Reports|December 22, 2024
Physiological shedding and C-terminal proteolytic processing of TMEM106BSebastian Held, Christian Erck, Susanna Kemppainen, et al.
Cells|January 8, 2023
Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse ModelJasenka Rudan Njavro, Marija Vukicevic, Emma Fiorini, et al.
Molecular Neurodegeneration|January 12, 2019
Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathologyMarc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, et al.
EMBO Molecular Medicine|May 25, 2019
Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolismJulia K Götzl, Matthias Brendel, Georg Werner, et al.
EMBO Molecular Medicine|November 29, 2018
CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive declineMarc Suárez-Calvet, Anja Capell, Miguel Ángel Araque Caballero, et al.
Journal of Neuroinflammation|February 24, 2023
Depletion and activation of microglia impact metabolic connectivity of the mouse brainJohannes Gnörich, Anika Reifschneider, Karin Wind, et al.
Science Translational Medicine|June 5, 2024
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degenerationMarvin Reich, Matthew J Simon, Beate Polke, et al.
The EMBO Journal|January 12, 2022
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiencyAnika Reifschneider, Sophie Robinson, Bettina van Lengerich, et al.
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