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Bioorganic & Medicinal Chemistry Letters|June 29, 2017
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systemsSabin Llona-Minguez, Maria Häggblad, Ulf Martens, et al.Journal of Medicinal Chemistry|April 10, 2009
Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3Lari Lehtiö, Ann-Sofie Jemth, Ruairi Collins, et al.Nucleic Acids Research|October 11, 2018
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTPAnn-Sofie Jemth, Robert Gustafsson, Lars Bräutigam, et al.The Biochemical Journal|March 20, 2015
Processing of protein ADP-ribosylation by Nudix hydrolasesLuca Palazzo, Benjamin Thomas, Ann-Sofie Jemth, et al.Cancer Research|February 11, 2016
Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 InhibitionLars Bräutigam, Linda Pudelko, Ann-Sofie Jemth, et al.Cancer Research|August 18, 2016
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-ThioguanineNicholas C K Valerie, Anna Hagenkort, Brent D G Page, et al.Nature Communications|August 5, 2015
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2Megan Carter, Ann-Sofie Jemth, Anna Hagenkort, et al.Cancer Research|December 1, 2016
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based InhibitorRobert Gustafsson, Ann-Sofie Jemth, Nina M S Gustafsson, et al.Oncotarget|April 21, 2017
dUTPase inhibition augments replication defects of 5-FluorouracilAnna Hagenkort, Cynthia B J Paulin, Matthieu Desroses, et al.Nature Communications|June 2, 2026
Structural basis for uracil removal from DNA by human SMUG1Julian M Ludäscher, Emma Scaletti Hutchinson, Guillem Vila-Julià, et al.Pageof 6