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ACS Medicinal Chemistry Letters|March 25, 2017
Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart FailureMarion Lanier, Jason Pickens, Simone V Bigi, et al.ACS Medicinal Chemistry Letters|December 21, 2017
Correction to "Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure"Marion Lanier, Jason Pickens, Simone V Bigi, et al.Journal of Medicinal Chemistry|December 29, 2023
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray CocrystallographyChristopher R Smith, Dan Chen, James G Christensen, et al.Journal of Medicinal Chemistry|January 18, 2022
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of <i>MTAP</i>-Deleted CancersChristopher R Smith, Ruth Aranda, Thomas P Bobinski, et al.Journal of Medicinal Chemistry|July 14, 2022
Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein InteractionJohn M Ketcham, Jacob Haling, Shilpi Khare, et al.Journal of Medicinal Chemistry|March 13, 2024
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant ProteinJohn M Ketcham, Stephen J Harwood, Ruth Aranda, et al.Molecular Cancer Therapeutics|June 21, 2024
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide LoadingNiranjan Sudhakar, Larry Yan, Fadia Qiryaqos, et al.Pageof 3