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European Journal of Medicinal Chemistry|March 24, 2022
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivitySabina Sblano, Carmen Cerchia, Antonio Laghezza, et al.European Journal of Medicinal Chemistry|December 16, 2014
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175Luca Piemontese, Giuseppe Fracchiolla, Antonio Carrieri, et al.The Journal of Biological Chemistry|April 4, 2007
Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligandsGiorgio Pochetti, Cristina Godio, Nico Mitro, et al.Scientific Reports|November 2, 2017
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 DiabetesSabina Yasmin, Fabio Capone, Antonio Laghezza, et al.Antioxidants (Basel, Switzerland)|September 23, 2022
Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer's DiseaseAlessia Carocci, Alexia Barbarossa, Rosalba Leuci, et al.Bioorganic Chemistry|October 25, 2024
Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer's drug candidatesRosalba Leuci, Stefan Simic, Antonio Carrieri, et al.Journal of Medicinal Chemistry|December 5, 2008
Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug designRoberta Montanari, Fulvio Saccoccia, Elena Scotti, et al.Chemmedchem|February 3, 2015
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal musclesAntonio Laghezza, Roberta Montanari, Antonio Lavecchia, et al.Archiv Der Pharmazie|May 28, 2024
Synthesis and in vitro cytotoxicity of benzoxazole-based PPARα/γ antagonists in colorectal cancer cell linesNazaret Moreno-Rodríguez, Antonio Laghezza, Carmen Cerchia, et al.European Journal of Medicinal Chemistry|April 24, 2022
Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's diseaseLeonardo Brunetti, Rosalba Leuci, Antonio Carrieri, et al.Pageof 8