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Journal of Medicinal Chemistry|May 14, 2010
Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesisGiorgio Pochetti, Nico Mitro, Antonio Lavecchia, et al.
The Journal of Biological Chemistry|January 24, 2014
LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic propertiesFederica Gilardi, Marco Giudici, Nico Mitro, et al.
ACS Medicinal Chemistry Letters|May 22, 2020
Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking StudiesAlessandra Ammazzalorso, Isabella Bruno, Rosalba Florio, et al.
Toxicology and Applied Pharmacology|July 6, 2016
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatinGiulia Maria Camerino, Michela De Bellis, Elena Conte, et al.
European Journal of Medicinal Chemistry|September 15, 2018
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesisSalvatore Savino, Annamaria Toscano, Rosa Purgatorio, et al.
Chemmedchem|October 8, 2020
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic EffectsSabina Yasmin, Carmen Cerchia, Vishnu Nayak Badavath, et al.
Bioorganic Chemistry|July 10, 2026
Virtual screening-guided repurposing of fluorescent probes to detect EGFR expression in renal cellsGiovanni Graziano, Daniela Trisciuzzi, Marialessandra Contino, et al.
Journal of Medicinal Chemistry|February 15, 2023
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier InhibitionAntonio Laghezza, Carmen Cerchia, Massimo Genovese, et al.
ACS Medicinal Chemistry Letters|April 19, 2019
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic SyndromeLetizia Giampietro, Antonio Laghezza, Carmen Cerchia, et al.
European Journal of Medicinal Chemistry|March 15, 2025
A new potent and selective peroxisome proliferator-activated receptor alpha partial agonist displays anti-steatotic effects In vitro and behaves as a safe hypolipidemic and hypoglycemic agent in a diabetic mouse modelAntonio Laghezza, Emanuele Falbo, Federica Gilardi, et al.
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