Showing results (11-20 of 26) with videos related to
Sort By:
Pageof 3
Journal of Medicinal Chemistry|January 29, 2014
Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virusSteven R LaPlante, Anil K Padyana, Asitha Abeywardane, et al.Bioorganic & Medicinal Chemistry Letters|November 2, 2013
Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assayTimothy A Stammers, René Coulombe, Martin Duplessis, et al.Bioorganic & Medicinal Chemistry Letters|April 3, 2013
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitorsTimothy A Stammers, René Coulombe, Jean Rancourt, et al.Journal of Medicinal Chemistry|October 29, 2013
Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: discovery of deleobuvir (BI 207127)Steven R LaPlante, Michael Bös, Christian Brochu, et al.Bioorganic & Medicinal Chemistry Letters|June 23, 2007
Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptasesAlexandre Gagnon, Ma'an H Amad, Pierre R Bonneau, et al.Bioorganic & Medicinal Chemistry Letters|June 18, 2013
Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotypePierre L Beaulieu, René Coulombe, Jianmin Duan, et al.Bioorganic & Medicinal Chemistry Letters|August 16, 2006
Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffoldsPierre L Beaulieu, James Gillard, Darren Bykowski, et al.Bioorganic & Medicinal Chemistry Letters|January 16, 2010
N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studiesPierre L Beaulieu, Eric Jolicoeur, James Gillard, et al.ACS Medicinal Chemistry Letters|June 20, 2014
Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIVLee D Fader, Rebekah Carson, Sébastien Morin, et al.Antimicrobial Agents and Chemotherapy|March 26, 2014
Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitorCraig Fenwick, Ma'an Amad, Murray D Bailey, et al.Pageof 3